PMID- 35481273
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease.
PG  - 861714
LID - 10.3389/fneur.2022.861714 [doi]
LID - 861714
AB  - Cerebral small vessel disease (CSVD) poses a serious socio-economic burden due to 
      its high prevalence and severe impact on the quality of life of elderly patients. 
      Pathological changes in CSVD mainly influence small cerebral arteries, 
      microarteries, capillaries, and small veins, which are usually caused by multiple 
      vascular risk factors. CSVD is often identified on brain magnetic resonance 
      imaging (MRI) by recent small subcortical infarcts, white matter 
      hyperintensities, lacune, cerebral microbleeds (CMBs), enlarged perivascular 
      spaces (ePVSs), and brain atrophy. Endothelial cell (EC) dysfunction is earlier 
      than clinical symptoms. Immune activation, inflammation, and oxidative stress may 
      be potential mechanisms of EC injury. ECs of the blood-brain-barrier (BBB) are 
      the most important part of the neurovascular unit (NVU) that ensures constant 
      blood flow to the brain. Impaired cerebral vascular autoregulation and disrupted 
      BBB cause cumulative brain damage. This review will focus on the role of EC 
      injury in CSVD. Furthermore, several specific biomarkers will be discussed, which 
      may be useful for us to assess the endothelial dysfunction and explore new 
      therapeutic directions.
CI  - Copyright (c) 2022 Bai, Yu and Feng.
FAU - Bai, Tao
AU  - Bai T
AD  - Department of Neurology, Shengjing Hospital of China Medical University, China 
      Medical University, Shen yang, China.
FAU - Yu, Shijia
AU  - Yu S
AD  - Department of Neurology, Shengjing Hospital of China Medical University, China 
      Medical University, Shen yang, China.
FAU - Feng, Juan
AU  - Feng J
AD  - Department of Neurology, Shengjing Hospital of China Medical University, China 
      Medical University, Shen yang, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220411
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9035937
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cerebral small vessel disease (CSVD)
OT  - cognitive impairment
OT  - endothelial cells (ECs)
OT  - hypertension
OT  - white matter hyperintensities (WMH)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/29 06:00
MHDA- 2022/04/29 06:01
PMCR- 2022/04/11
CRDT- 2022/04/28 06:38
PHST- 2022/01/25 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/28 06:38 [entrez]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/04/29 06:01 [medline]
PHST- 2022/04/11 00:00 [pmc-release]
AID - 10.3389/fneur.2022.861714 [doi]
PST - epublish
SO  - Front Neurol. 2022 Apr 11;13:861714. doi: 10.3389/fneur.2022.861714. eCollection 
      2022.