PMID- 35483919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220512
IS  - 2287-979X (Print)
IS  - 2288-0011 (Electronic)
IS  - 2287-979X (Linking)
VI  - 57
IP  - S1
DP  - 2022 Apr 30
TI  - Evaluation and management of platelet transfusion refractoriness.
PG  - 6-10
LID - 10.5045/br.2022.2021229 [doi]
AB  - Platelet transfusion refractoriness (PTR), in which platelet counts do not 
      increase after transfusion, occurs in many patients receiving platelet 
      transfusions. PTR is a clinical condition that can harm patients. The causes of 
      PTR can be divided into two types: immune and non-immune. Most cases of PTR are 
      non-immune. Among immune causes, the most common is human leukocyte antigen (HLA) 
      class I molecules. PTR caused by anti-HLA antibodies is usually managed by 
      transfusing HLA-matched platelets. Therefore, it is important, especially for 
      hemato-oncologists who frequently perform transfusion, to accurately diagnose 
      whether the cause of platelet transfusion failure is alloimmune or 
      non-immunological when determining the treatment direction for the patient. In 
      this review, we discuss the definitions, causes, countermeasures, and prevention 
      methods of PTR.
FAU - Youk, Hee-Jeong
AU  - Youk HJ
AD  - Department of Laboratory Medicine, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Hwang, Sang-Hyun
AU  - Hwang SH
AD  - Department of Laboratory Medicine, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Oh, Heung-Bum
AU  - Oh HB
AD  - Department of Laboratory Medicine, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Ko, Dae-Hyun
AU  - Ko DH
AD  - Department of Laboratory Medicine, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Blood Res
JT  - Blood research
JID - 101605247
PMC - PMC9057673
OTO - NOTNLM
OT  - HLA-matched
OT  - Human leukocyte antigen
OT  - Platelet count
OT  - Platelet transfusion
OT  - Platelet transfusion refractoriness
COIS- Authors' Disclosures of Potential Conflicts of Interest No potential conflicts of 
      interest relevant to this article were reported.
EDAT- 2022/04/29 06:00
MHDA- 2022/04/29 06:01
PMCR- 2022/04/30
CRDT- 2022/04/28 21:42
PHST- 2021/12/29 00:00 [received]
PHST- 2022/01/13 00:00 [accepted]
PHST- 2022/04/28 21:42 [entrez]
PHST- 2022/04/29 06:00 [pubmed]
PHST- 2022/04/29 06:01 [medline]
PHST- 2022/04/30 00:00 [pmc-release]
AID - br.2022.2021229 [pii]
AID - br-57-s1-s6 [pii]
AID - 10.5045/br.2022.2021229 [doi]
PST - ppublish
SO  - Blood Res. 2022 Apr 30;57(S1):6-10. doi: 10.5045/br.2022.2021229.