PMID- 35484956
OWN - NLM
STAT- MEDLINE
DCOM- 20220704
LR  - 20220719
IS  - 2472-1727 (Electronic)
VI  - 114
IP  - 11
DP  - 2022 Jul 1
TI  - Gestational purple grape juice consumption does not change fetal ductus 
      arteriosus constriction in Wistar rats.
PG  - 525-535
LID - 10.1002/bdr2.2018 [doi]
AB  - Grape juice consumption may influence the early occurrence of ductal constriction 
      during pregnancy, since the consumption of foods rich in polyphenols can be 
      linked to the premature constriction of the ductus arteriosus. This study aimed 
      to evaluate the effect of purple grape juice consumption during gestation on 
      fetal ductus arteriosus closure, prostaglandin levels, and oxidative stress 
      markers in Wistar rats. We divided 18 pregnant rats into four groups: a control 
      group (C), a single-dose grape juice group (SDGJ), a two-dose grape juice group 
      (TDGJ) of 7 mul/g body weight per day, and an indomethacin group (I). Blood was 
      collected on gestational day (GD) 0, 14, and 20. Prostaglandin levels were 
      measured, and the livers and hearts were removed from the mothers and fetuses for 
      oxidative stress analysis; histology of the fetal ductus arteriosus was 
      performed. Prostaglandin levels (pg/ml) at GD 20 were (C:1462.10 +/- 314.61); 
      (SDGJ:987.66 +/- 86.25); (TDGJ:1290.00 +/- 221.57), and (I:584.75 +/- 46.77). Fetal 
      ductus arteriosus closure occurred only in the indomethacin group. Lipid 
      peroxidation evaluated through thiobarbituric acid reactive substances (nmol/mg 
      protein) in maternal livers was lower in the grape juice groups (C: 
      4.11 +/- 0.76 nmol/mg protein), (SDGJ: 2.34 +/- 0.36), (TDGJ: 1.52 +/- 0.18), and (I: 
      4.20 +/- 0.76). Sulfhydryls (nmol/mg protein) were lower in the TDGJ group 
      (C:763.59 +/- 61.38 nmol/mg protein), (SDGJ:978.88 +/- 158.81), 
      (TDGJ:385.32 +/- 86.78), and (I:727.72 +/- 49.12). Also, superoxide dismutase 
      activity (USOD/mg protein) was higher in fetal hearts in this group: 
      (C:5.29 +/- 0.33), (SDGJ:4.48 +/- 0.47), (TDGJ:7.35 +/- 0.43), and (I:6.00 +/- 0.18). We 
      conclude that grape juice consumption in pregnancy does not induce ductus 
      arteriosus closure in the fetus and presented potential antioxidant effects.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Proenca, Isabel Cristina Teixeira
AU  - Proenca ICT
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Miri, Malena Rostirola
AU  - Miri MR
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Marinho, Jessica Pereira
AU  - Marinho JP
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Bock, Patricia Martins
AU  - Bock PM
AUID- ORCID: 0000-0001-8572-3950
AD  - Integraded Colleges of Taquara, Rua Oscar Martins Rangel, Taquara, RS, Brazil.
FAU - de Abreu, Tamires Marques
AU  - de Abreu TM
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Pinto, Milene Santana
AU  - Pinto MS
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Blembeel, Amanda Stolzenberg
AU  - Blembeel AS
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Ferreira, Aimee Souto
AU  - Ferreira AS
AD  - Experimental Research Center, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      RS, Brazil.
FAU - Andrades, Michael
AU  - Andrades M
AUID- ORCID: 0000-0003-0337-9661
AD  - Experimental Research Center, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      RS, Brazil.
FAU - da Rosa Araujo, Alex Sander
AU  - da Rosa Araujo AS
AUID- ORCID: 0000-0002-9482-7388
AD  - Department of Physiology, Federal University of Rio Grande do Sul - UFRGS, Porto 
      Alegre, RS, Brazil.
FAU - Funchal, Claudia
AU  - Funchal C
AUID- ORCID: 0000-0001-5781-0475
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Pochmann, Daniela
AU  - Pochmann D
AUID- ORCID: 0000-0003-1635-1609
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
FAU - Dani, Caroline
AU  - Dani C
AUID- ORCID: 0000-0003-0046-7148
AD  - Biochemistry Laboratory, Research Center, Methodist University Center, Porto 
      Alegre Institute, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220429
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
RN  - 0 (Prostaglandins)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Constriction
MH  - *Ductus Arteriosus
MH  - Female
MH  - Indomethacin/pharmacology
MH  - Pregnancy
MH  - Prostaglandins/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Vitis
OTO - NOTNLM
OT  - PGE2
OT  - descendants
OT  - fetal ductus arteriosus
OT  - indomethacin
OT  - oxidative stress
EDAT- 2022/04/30 06:00
MHDA- 2022/07/06 06:00
CRDT- 2022/04/29 03:23
PHST- 2022/03/11 00:00 [revised]
PHST- 2022/02/18 00:00 [received]
PHST- 2022/03/31 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/07/06 06:00 [medline]
PHST- 2022/04/29 03:23 [entrez]
AID - 10.1002/bdr2.2018 [doi]
PST - ppublish
SO  - Birth Defects Res. 2022 Jul 1;114(11):525-535. doi: 10.1002/bdr2.2018. Epub 2022 
      Apr 29.