PMID- 35484967
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20221214
IS  - 1738-8872 (Electronic)
IS  - 1017-7825 (Print)
IS  - 1017-7825 (Linking)
VI  - 32
IP  - 6
DP  - 2022 Jun 28
TI  - Pneumococcal Deltapep27 Immunization Attenuates TLRs and NLRP3 Expression and 
      Relieves Murine Ovalbumin-Induced Allergic Rhinitis.
PG  - 709-717
LID - 10.4014/jmb.2203.03006 [doi]
AB  - Allergic rhinitis (AR), one of the most common inflammatory diseases, is caused 
      by immunoglobulin E (IgE)-mediated reactions against inhaled allergens. AR 
      involves mucosal inflammation driven by type 2 helper T (Th2) cells. Previously, 
      it was shown that the Streptococcus pneumoniae pep27 mutant (Deltapep27) could 
      prevent and treat allergic asthma by reducing Th2 responses. However, the 
      underlying mechanism of Deltapep27 immunization in AR remains undetermined. Here, we 
      investigated the role of Deltapep27 immunization in the development and progression 
      of AR and elucidated potential mechanisms. In an ovalbumin (OVA)-induced AR mice 
      model, Deltapep27 alleviated allergic symptoms (frequency of sneezing and rubbing) 
      and reduced TLR2 and TLR4 expression, Th2 cytokines, and eosinophil infiltration 
      in the nasal mucosa. Mechanistically, Deltapep27 reduced the activation of the NLRP3 
      inflammasome in the nasal mucosa by down-regulating the Toll-like receptor 
      signaling pathway. In conclusion, Deltapep27 seems to alleviate TLR signaling and 
      NLRP3 inflammasome activation to subsequently prevent AR.
FAU - Yu, Jae Ik
AU  - Yu JI
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
FAU - Kim, Ji-Hoon
AU  - Kim JH
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
FAU - Nam, Ki-El
AU  - Nam KE
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
FAU - Lee, Wonsik
AU  - Lee W
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
FAU - Rhee, Dong-Kwon
AU  - Rhee DK
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
AD  - DNBio Pharm. Inc., Research Center, Sungkyunkwan University, Suwon 16419, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20220418
PL  - Korea (South)
TA  - J Microbiol Biotechnol
JT  - Journal of microbiology and biotechnology
JID - 9431852
RN  - 0 (Cytokines)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Immunization
MH  - Inflammasomes/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *NLR Family, Pyrin Domain-Containing 3 Protein/genetics
MH  - Ovalbumin
MH  - *Rhinitis, Allergic/chemically induced/metabolism/prevention & control
MH  - Th2 Cells
PMC - PMC9628895
OTO - NOTNLM
OT  - NLRP3 inflammasome
OT  - allergic rhinitis
OT  - toll-like receptor
OT  - Deltapep27
COIS- Conflict of Interest The authors have no financial conflicts of interest to 
      declare.
EDAT- 2022/04/30 06:00
MHDA- 2022/06/30 06:00
PMCR- 2022/04/18
CRDT- 2022/04/29 03:33
PHST- 2022/03/03 00:00 [received]
PHST- 2022/04/14 00:00 [revised]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
PHST- 2022/04/29 03:33 [entrez]
PHST- 2022/04/18 00:00 [pmc-release]
AID - jmb.2203.03006 [pii]
AID - jmb-32-6-709 [pii]
AID - 10.4014/jmb.2203.03006 [doi]
PST - ppublish
SO  - J Microbiol Biotechnol. 2022 Jun 28;32(6):709-717. doi: 10.4014/jmb.2203.03006. 
      Epub 2022 Apr 18.