PMID- 35485402
OWN - NLM
STAT- MEDLINE
DCOM- 20220727
LR  - 20220804
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 198
IP  - 3
DP  - 2022 Aug
TI  - A national service for delivering CD19 CAR-Tin large B-cell lymphoma - The UK 
      real-world experience.
PG  - 492-502
LID - 10.1111/bjh.18209 [doi]
AB  - CD19 CAR-T have emerged as a new standard treatment for relapsed/refractory (r/r) 
      large B-cell lymphoma (LBCL). CAR-T real-world (RW) outcomes published to date 
      suggest significant variability across countries. We provide results of a large 
      national cohort of patients intended to be treated with CAR-T in the UK. 
      Consecutive patients with r/r LBCL approved for CAR-T by the National CAR-T 
      Clinical Panel between December 2018 and November 2020 across all UK CAR-T 
      centres were included. 404/432 patients were approved [292 axicabtagene 
      ciloleucel (axi-cel), 112 tisagenlecleucel (tisa-cel)], 300 (74%) received the 
      cells. 110/300 (38.3%) patients achieved complete remission (CR) at 6 months (m). 
      The overall response rate was 77% (52% CR) for axi-cel, 57% (44% CR) for 
      tisa-cel. The 12-month progression-free survival was 41.8% (axi-cel) and 27.4% 
      (tisa-cel). Median overall survival for the intention-to-treat population was 
      10.5 m, 16.2 m for infused patients. The incidence of grade >/=3 cytokine release 
      syndrome and neurotoxicity were 7.6%/19.6% for axi-cel and 7.9%/3.9% for 
      tisa-cel. This prospective RW population of CAR-T eligible patients offers 
      important insights into the clinical benefit of CD19 CAR-T in LBCL in daily 
      practice. Our results confirm long-term efficacy in patients receiving treatment 
      similar to the pivotal trials, but highlight the significance of early CAR-T 
      failure.
CI  - (c) 2022 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Kuhnl, Andrea
AU  - Kuhnl A
AUID- ORCID: 0000-0002-4952-2550
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Roddie, Claire
AU  - Roddie C
AUID- ORCID: 0000-0002-4901-5858
AD  - Department of Haematology, University College London Hospitals, London, UK.
AD  - UCL Cancer Institute, University College London, London, UK.
FAU - Kirkwood, Amy A
AU  - Kirkwood AA
AD  - Cancer Research UK & UCL Cancer Trials Centre, UCL Cancer Institute, University 
      College London, London, UK.
FAU - Tholouli, Eleni
AU  - Tholouli E
AD  - Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
FAU - Menne, Tobias
AU  - Menne T
AUID- ORCID: 0000-0002-3289-2344
AD  - Department of Haematology, Freeman Hospital, Newcastle, UK.
FAU - Patel, Amit
AU  - Patel A
AD  - Department of Haematology, The Christie Hospital, Manchester, UK.
FAU - Besley, Caroline
AU  - Besley C
AD  - Department of Haematology, University Hospitals Bristol and Weston, Bristol, UK.
FAU - Chaganti, Sridhar
AU  - Chaganti S
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
FAU - Sanderson, Robin
AU  - Sanderson R
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - O'Reilly, Maeve
AU  - O'Reilly M
AUID- ORCID: 0000-0002-2702-397X
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Norman, Jane
AU  - Norman J
AD  - Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
FAU - Osborne, Wendy
AU  - Osborne W
AD  - Department of Haematology, Freeman Hospital, Newcastle, UK.
FAU - Bloor, Adrian
AU  - Bloor A
AUID- ORCID: 0000-0003-4550-220X
AD  - Department of Haematology, The Christie Hospital, Manchester, UK.
FAU - Lugthart, Sanne
AU  - Lugthart S
AD  - Department of Haematology, University Hospitals Bristol and Weston, Bristol, UK.
FAU - Malladi, Ram
AU  - Malladi R
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
AD  - Department of Haematology, Addenbrookes Hospital, Cambridge, UK.
FAU - Patten, Piers E M
AU  - Patten PEM
AD  - Department of Haematology, King's College Hospital, London, UK.
AD  - Comprehensive Cancer Centre, King's College London, London, UK.
FAU - Neill, Lorna
AU  - Neill L
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Martinez-Cibrian, Nuria
AU  - Martinez-Cibrian N
AD  - Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
FAU - Kennedy, Hannah
AU  - Kennedy H
AD  - Department of Haematology, Freeman Hospital, Newcastle, UK.
FAU - Phillips, Elizabeth H
AU  - Phillips EH
AUID- ORCID: 0000-0001-9316-7544
AD  - Department of Medical Oncology, The Christie Hospital, Manchester, UK.
AD  - Division of Cancer Sciences, University of Manchester, Manchester, UK.
FAU - Jones, Ceri
AU  - Jones C
AD  - Department of Haematology, University Hospital of Wales, Cardiff, UK.
FAU - Sharplin, Kirsty
AU  - Sharplin K
AD  - Department of Haematology, University Hospitals Bristol and Weston, Bristol, UK.
FAU - El-Sharkawi, Dima
AU  - El-Sharkawi D
AUID- ORCID: 0000-0002-2752-5814
AD  - Department of Haematology, Royal Marsden Hospital, London, UK.
FAU - Latif, Anne-Louise
AU  - Latif AL
AD  - Department of Haematology, Queen Elizabeth II Hospital, Glasgow, UK.
FAU - Mathew, Amrith
AU  - Mathew A
AD  - Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
FAU - Uttenthal, Benjamin
AU  - Uttenthal B
AD  - Department of Haematology, Addenbrookes Hospital, Cambridge, UK.
FAU - Stewart, Orla
AU  - Stewart O
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Marzolini, Maria A V
AU  - Marzolini MAV
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Townsend, William
AU  - Townsend W
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Cwynarski, Kate
AU  - Cwynarski K
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Ardeshna, Kirit
AU  - Ardeshna K
AD  - Department of Haematology, University College London Hospitals, London, UK.
FAU - Ardavan, Arzhang
AU  - Ardavan A
AD  - NCRI Consumer Forum, London, UK.
AD  - Department of Physics, University of Oxford, UK.
FAU - Robinson, Kate
AU  - Robinson K
AD  - NCRI Consumer Forum, London, UK.
FAU - Pagliuca, Antonio
AU  - Pagliuca A
AD  - Department of Haematology, King's College Hospital, London, UK.
FAU - Collins, Graham P
AU  - Collins GP
AD  - Department of Haematology, Oxford University Hospital, Oxford, UK.
FAU - Johnson, Roderick
AU  - Johnson R
AUID- ORCID: 0000-0002-0441-8688
AD  - Department of Haematology, St. James's Hospital, Leeds, UK.
FAU - McMillan, Andrew
AU  - McMillan A
AD  - Department of Haematology, Nottingham University Hospitals, Nottingham, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220429
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Antigens, CD19)
RN  - 0 (Receptors, Chimeric Antigen)
SB  - IM
MH  - Antigens, CD19/therapeutic use
MH  - Cytokine Release Syndrome
MH  - Humans
MH  - *Immunotherapy, Adoptive/methods
MH  - *Lymphoma, Large B-Cell, Diffuse/drug therapy
MH  - Prospective Studies
MH  - *Receptors, Chimeric Antigen
MH  - United Kingdom/epidemiology
OTO - NOTNLM
OT  - cellular therapies
OT  - lymphoid malignancies
OT  - lymphomas
EDAT- 2022/04/30 06:00
MHDA- 2022/07/28 06:00
CRDT- 2022/04/29 06:33
PHST- 2022/03/22 00:00 [revised]
PHST- 2022/01/25 00:00 [received]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/07/28 06:00 [medline]
PHST- 2022/04/29 06:33 [entrez]
AID - 10.1111/bjh.18209 [doi]
PST - ppublish
SO  - Br J Haematol. 2022 Aug;198(3):492-502. doi: 10.1111/bjh.18209. Epub 2022 Apr 29.