PMID- 35486295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2090-5920 (Electronic)
IS  - 1687-157X (Print)
IS  - 1687-157X (Linking)
VI  - 20
IP  - 1
DP  - 2022 Apr 29
TI  - Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in 
      type 2 diabetes mellitus patients.
PG  - 68
LID - 10.1186/s43141-022-00349-w [doi]
LID - 68
AB  - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) showed significant 
      association with PNPLA3 rs738409 polymorphism in unrelated individuals. However, 
      it is still unknown whether the relationship of NAFLD with PNPLA3 variant exists 
      or not among subjects with type 2 diabetes mellitus (T2DM). Therefore, the study 
      aimed to evaluate sociodemographic and genetic determinants of NAFLD in type 2 
      diabetics. METHODS: The cross-sectional analytical study was conducted at the 
      Department of Molecular Biology, Virtual University of Pakistan, Lahore, 
      Pakistan, during 2019-2020. A total of 153 known cases of T2DM were enrolled 
      using convenience sampling. After excluding patients (n = 24) with HCV, 
      alcoholism, or missing information, data from 129 eligible diabetics with and 
      without NAFLD were analyzed using SPSS. Odds ratios using crosstabs and adjusted 
      odds ratios using binary and multinomial logistic regression were calculated to 
      measure the risk of NAFLD. RESULTS: Adults 18-35 years were 7.0%, 36-55 years 
      were 64.3%, >/= 56 years were 28.7%, and females were 66.7%. A total of 41.1% of 
      patients had obesity, 52.7% had NAFLD, and 29.05% carried mutant G allele of 
      rs738409 polymorphism. Among overall diabetics, NAFLD showed association with 
      female (OR = 2.998, p = 0.007), illiterate (OR = 3.067, p = 0.005), and obese (OR 
      = 2.211, p = 0.046) but not with PNPLA3 genotype under any model (all p = > 
      0.05). Among obese diabetics, NAFLD showed association with female (AOR = 4.010, 
      p = 0.029), illiterate (AOR = 3.506, p = 0.037), GG + CG/CC (AOR = 3.303, p = 
      0.033), and GG/CG + CC (AOR = 4.547, p = 0.034) using binary regression and with 
      female (AOR = 3.411, p = 0.051), illiterate (AOR = 3.323, p = 0.048), GG + CG/CC 
      (AOR = 3.270, p = 0.029), and GG/CG + CC (AOR = 4.534, p = 0.024) using 
      multinomial regression. CONCLUSIONS: NAFLD and obesity were the most common 
      comorbid diseases of T2DM. Gender female, being illiterate, and PNPLA3 rs738409 
      polymorphism were significant risk factors of NAFLD among obese diabetic 
      patients.
CI  - (c) 2022. The Author(s).
FAU - Adnan, Muhammad
AU  - Adnan M
AUID- ORCID: 0000-0001-7255-9450
AD  - Health Research Institute, National Institute of Health, Lahore, Pakistan. 
      adnanpmrc@gmail.com.
AD  - Department of Molecular Biology, Virtual University of Pakistan, Lahore, 
      Pakistan. adnanpmrc@gmail.com.
FAU - Wajid, Abdul
AU  - Wajid A
AD  - Department of Molecular Biology, Virtual University of Pakistan, Lahore, 
      Pakistan.
FAU - Noor, Wasif
AU  - Noor W
AD  - Diabetes Clinic, Sir Ganga Ram Hospital, Lahore, Pakistan.
FAU - Batool, Andleeb
AU  - Batool A
AD  - Department of Zoology, Government College University, Lahore, Pakistan.
FAU - Aasim, Muhammad
AU  - Aasim M
AD  - Health Research Institute, National Institute of Health, Lahore, Pakistan.
FAU - Abbas, Kamran
AU  - Abbas K
AD  - Department of Molecular Biology, Virtual University of Pakistan, Lahore, 
      Pakistan.
FAU - Ain, Quratul
AU  - Ain Q
AD  - Department of Molecular Biology, Virtual University of Pakistan, Lahore, 
      Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20220429
PL  - Netherlands
TA  - J Genet Eng Biotechnol
JT  - Journal, genetic engineering & biotechnology
JID - 101317150
PMC - PMC9054952
OTO - NOTNLM
OT  - Diabetes mellitus type 2
OT  - Nonalcoholic fatty liver disease
OT  - Obesity
OT  - Polymorphism genetic
OT  - Risk factors
COIS- The authors declare that they have no competing interests.
EDAT- 2022/04/30 06:00
MHDA- 2022/04/30 06:01
PMCR- 2022/04/29
CRDT- 2022/04/29 11:19
PHST- 2021/10/27 00:00 [received]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/04/29 11:19 [entrez]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/04/30 06:01 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - 10.1186/s43141-022-00349-w [pii]
AID - 349 [pii]
AID - 10.1186/s43141-022-00349-w [doi]
PST - epublish
SO  - J Genet Eng Biotechnol. 2022 Apr 29;20(1):68. doi: 10.1186/s43141-022-00349-w.