PMID- 35486636
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220622
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 4
DP  - 2022
TI  - The clinical value of miRNA-21 in cervical cancer: A comprehensive investigation 
      based on microarray datasets.
PG  - e0267108
LID - 10.1371/journal.pone.0267108 [doi]
LID - e0267108
AB  - Previous work has demonstrated that the expression of microRNA-21 (miR-21) is 
      implicated in cervical cancer (CC). However, little is known regarding its 
      associations with clinical parameters. We first conducted a meta-analysis using 
      data from Gene Expression Omnibus (GEO) microarrays and The Cancer Genome Atlas 
      (TCGA). Then, enrichment analysis and hub gene screening were performed by 
      bioinformatic methods. Finally, the role of the screened target genes in CC was 
      explored. According to the meta-analysis, the expression of miR-21 in cancer 
      tissues was higher than in adjacent nontumor tissues (P < 0.05). In addition, 46 
      genes were predicted as potential targets of miR-21. After enrichment analyses, 
      it was detected that these genes were enriched in various cancer pathways, 
      including the phosphatidylinositol signaling system and mammalian target of 
      rapamycin (mTOR) signaling pathway. In this study, bioinformatic tools and 
      meta-analysis validated that miR-21 may function as a highly sensitive and 
      specific marker for the diagnosis of CC, which may provide a novel approach to 
      the diagnosis and treatment of CC.
FAU - Deng, Zhi-Min
AU  - Deng ZM
AUID- ORCID: 0000-0003-4760-4293
AD  - Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, 
      Wuhan, Hubei, China.
FAU - Chen, Gan-Hong
AU  - Chen GH
AD  - Department of Pathology, The People's Hospital of Honghu, Honghu, Hubei, China.
FAU - Dai, Fang-Fang
AU  - Dai FF
AD  - Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, 
      Wuhan, Hubei, China.
FAU - Liu, Shi-Yi
AU  - Liu SY
AD  - Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, 
      Wuhan, Hubei, China.
FAU - Yang, Dong-Yong
AU  - Yang DY
AD  - Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, 
      Wuhan, Hubei, China.
FAU - Bao, An-Yu
AU  - Bao AY
AD  - Department of Clinical laboratory, Renmin Hospital of Wuhan University, Wuhan, 
      Hubei, China.
FAU - Cheng, Yan-Xiang
AU  - Cheng YX
AD  - Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, 
      Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20220429
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Computational Biology/methods
MH  - Female
MH  - Gene Expression Profiling/methods
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - *Uterine Cervical Neoplasms/genetics
PMC - PMC9053781
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/04/30 06:00
MHDA- 2022/05/04 06:00
PMCR- 2022/04/29
CRDT- 2022/04/29 13:44
PHST- 2021/02/02 00:00 [received]
PHST- 2022/04/03 00:00 [accepted]
PHST- 2022/04/29 13:44 [entrez]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - PONE-D-21-03458 [pii]
AID - 10.1371/journal.pone.0267108 [doi]
PST - epublish
SO  - PLoS One. 2022 Apr 29;17(4):e0267108. doi: 10.1371/journal.pone.0267108. 
      eCollection 2022.