PMID- 35487173
OWN - NLM
STAT- MEDLINE
DCOM- 20220509
LR  - 20220509
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 237
DP  - 2022 Jun 1
TI  - Effects of the maternal gut microbiome and gut-placental axis on melatonin 
      efficacy in alleviating cadmium-induced fetal growth restriction.
PG  - 113550
LID - S0147-6513(22)00390-6 [pii]
LID - 10.1016/j.ecoenv.2022.113550 [doi]
AB  - Cadmium (Cd) is a major environmental stressor that induces fetal growth 
      restriction (FGR). Also, changes in gut microbiome diversity-which can be 
      modulated positively by melatonin (Mel) have implications on fetal development 
      and placental functions. Therefore, this study aimed to explore whether the role 
      of Mel in counteracting the Cd-induced FGR by regulating placental barrier 
      injury, endoplasmic reticulum stress (ERS) and mitophagy in pregnant mice is 
      mediated-in part- via the gut microbiota modulations. Pregnant mice were 
      intraperitoneally injected with CdCl(2) (5 mg/kg) and Mel (5 mg/kg) once daily, 
      respectively, at the same time from gestational day (GD) 8 to GD18, and then the 
      maternal colon and placental tissues were collected for detection. To investigate 
      the inner relationship between intestinal flora and the protection of Mel on FGR 
      caused by Cd, gut microbiota transplantation (GMT) was carried out from GD0 to 
      GD18 after the removal of intestinal microbiota by antibiotics. Results indicated 
      that Mel relieved barrier injury, ERS and mitophagy in the placenta, and reversed 
      the maternal gut microbiota dysbiosis. The GMT approach suggested a role of 
      intestinal microbiota in placental barrier injury, ERS and mitophagy induced by 
      Cd. Overall, the results highlighted that the intestinal microbiota and 
      gut-placental axis play a central role in the protective effect of Mel against 
      Cd-induced FGR.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Hao
AU  - Zhang H
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Liu, Xiaoyun
AU  - Liu X
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Zheng, Yi
AU  - Zheng Y
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Zha, Xia
AU  - Zha X
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Elsabagh, Mabrouk
AU  - Elsabagh M
AD  - Department of Animal Production and Technology, Faculty of Agricultural Sciences 
      and Technologies, Nigde Omer Halisdemir University, Nigde 51240, Turkey; 
      Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, 
      Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Ma, Yi
AU  - Ma Y
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Loor, Juan J
AU  - Loor JJ
AD  - Department of Animal Sciences, Division of Nutritional Sciences, University of 
      Illinois, Urbana 61801, USA.
FAU - Wang, Mengzhi
AU  - Wang M
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China.
FAU - Wang, Hongrong
AU  - Wang H
AD  - Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of 
      Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; 
      Joint International Research Laboratory of Agriculture and Agri-Product Safety, 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR 
      China. Electronic address: hrwang@yzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220426
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 00BH33GNGH (Cadmium)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Cadmium/toxicity
MH  - Female
MH  - Fetal Growth Retardation/chemically induced
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Melatonin/pharmacology/therapeutic use
MH  - Mice
MH  - Placenta
MH  - Pregnancy
OTO - NOTNLM
OT  - Cadmium
OT  - Fetal growth restriction
OT  - Gut microbiota
OT  - Gut-placenta axis
OT  - Melatonin
EDAT- 2022/04/30 06:00
MHDA- 2022/05/10 06:00
CRDT- 2022/04/29 18:27
PHST- 2021/11/26 00:00 [received]
PHST- 2022/04/14 00:00 [revised]
PHST- 2022/04/19 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/05/10 06:00 [medline]
PHST- 2022/04/29 18:27 [entrez]
AID - S0147-6513(22)00390-6 [pii]
AID - 10.1016/j.ecoenv.2022.113550 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Jun 1;237:113550. doi: 10.1016/j.ecoenv.2022.113550. 
      Epub 2022 Apr 26.