PMID- 35487576
OWN - NLM
STAT- MEDLINE
DCOM- 20220825
LR  - 20220829
IS  - 1543-2742 (Electronic)
IS  - 1526-484X (Linking)
VI  - 32
IP  - 5
DP  - 2022 Sep 1
TI  - Ketone Monoester Ingestion Alters Metabolism and Simulated Rugby Performance in 
      Professional Players.
PG  - 334-341
LID - 10.1123/ijsnem.2021-0346 [doi]
AB  - Ketone ingestion can alter metabolism but effects on exercise performance are 
      unclear, particularly with regard to the impact on intermittent-intensity 
      exercise and team-sport performance. Nine professional male rugby union players 
      each completed two trials in a double-blind, randomized, crossover design. 
      Participants ingested either 90 +/- 9 g carbohydrate (CHO; 9% solution) or an 
      energy matched solution containing 20 +/- 2 g CHO (3% solution) and 590 mg/kg body 
      mass beta-hydroxybutyrate monoester (CHO + BHB-ME) before and during a simulated 
      rugby union-specific match-play protocol, including repeated high-intensity, 
      sprint and power-based performance tests. Mean time to complete the sustained 
      high-intensity performance tests was reduced by 0.33 +/- 0.41 s (2.1%) with CHO + 
      BHB-ME (15.53 +/- 0.52 s) compared with CHO (15.86 +/- 0.80 s) placebo (p = .04). 
      Mean time to complete the sprint and power-based performance tests were not 
      different between trials. CHO + BHB-ME resulted in blood BHB concentrations that 
      remained >2 mmol/L during exercise (p < .001). Serum lactate and glycerol 
      concentrations were lower after CHO + BHB-ME than CHO (p < .05). Coingestion of a 
      BHB-ME with CHO can alter fuel metabolism (attenuate circulating lactate and 
      glycerol concentrations) and may improve high-intensity running performance 
      during a simulated rugby match-play protocol, without improving shorter duration 
      sprint and power-based efforts.
FAU - Peacock, Oliver J
AU  - Peacock OJ
AUID- ORCID: 0000-0002-2435-2903
AD  - Department for Health, University of Bath, Bath,United Kingdom.
AD  - Centre for Nutrition, Exercise and Metabolism, University of Bath, Bath,United 
      Kingdom.
FAU - Gonzalez, Javier T
AU  - Gonzalez JT
AD  - Department for Health, University of Bath, Bath,United Kingdom.
AD  - Centre for Nutrition, Exercise and Metabolism, University of Bath, Bath,United 
      Kingdom.
FAU - Roberts, Simon P
AU  - Roberts SP
AD  - Department for Health, University of Bath, Bath,United Kingdom.
FAU - Smith, Alan
AU  - Smith A
AD  - Department for Health, University of Bath, Bath,United Kingdom.
AD  - UK Sport Council, London,United Kingdom.
FAU - Drawer, Scott
AU  - Drawer S
AD  - UK Sport Council, London,United Kingdom.
FAU - Stokes, Keith A
AU  - Stokes KA
AD  - Department for Health, University of Bath, Bath,United Kingdom.
AD  - Rugby Football Union, Twickenham,United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220429
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Ketones)
RN  - 33X04XA5AT (Lactic Acid)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - *Athletic Performance
MH  - Dietary Carbohydrates
MH  - Double-Blind Method
MH  - Eating
MH  - Glycerol
MH  - Humans
MH  - Ketones
MH  - Lactic Acid
MH  - Male
MH  - Rugby
OTO - NOTNLM
OT  - athletes
OT  - exercise performance
OT  - glycerol
OT  - lactate
OT  - team sport
OT  - beta-hydroxybutyrate
EDAT- 2022/04/30 06:00
MHDA- 2022/08/26 06:00
CRDT- 2022/04/29 20:43
PHST- 2021/12/20 00:00 [received]
PHST- 2022/03/15 00:00 [revised]
PHST- 2022/03/15 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/08/26 06:00 [medline]
PHST- 2022/04/29 20:43 [entrez]
AID - 10.1123/ijsnem.2021-0346 [doi]
PST - epublish
SO  - Int J Sport Nutr Exerc Metab. 2022 Apr 29;32(5):334-341. doi: 
      10.1123/ijsnem.2021-0346. Print 2022 Sep 1.