PMID- 35487594
OWN - NLM
STAT- MEDLINE
DCOM- 20220512
LR  - 20220518
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 60
IP  - 6
DP  - 2022 May 25
TI  - Reference intervals for Sysmex XN hematological parameters as assessed in the 
      Dutch Lifelines cohort.
PG  - 907-920
LID - 10.1515/cclm-2022-0094 [doi]
AB  - OBJECTIVES: Our aim was to derive reference intervals for all Sysmex XN 
      hematology analyzer parameters. The rationale behind the study was the lack of 
      reference intervals for the XN analyzer cell population data (CPD) and functional 
      parameters. METHODS: Fresh fasting blood samples from 18,484 participants in the 
      Dutch Lifelines study were analyzed using two automated XN analyzers. Structured 
      health questionnaire data were used to select a subgroup of 15,803 apparently 
      healthy individuals for inclusion in the reference population. The Latent 
      Abnormal Values Exclusion (LAVE) approach was used to reduce the influence of 
      latent diseases in the reference population on the resulting reference intervals. 
      We applied analysis of variance to judge the need for partitioning of the 
      reference intervals by sex or age. RESULTS: We report reference intervals for 105 
      XN analyzer hematological parameters with and without applying LAVE. Sex-related 
      partitioning was required for red blood cells, (RBC, RBC-O), hemoglobin (HGB, 
      HGB-O), hematocrit (HCT), mean corpuscular hemoglobin concentration (MCHC), 
      reticulocyte production index (RPI), and side scattered light intensity of the 
      red blood cell population in the RET channel (RBC-Z). Partitioning for age was 
      not warranted. Body mass index (BMI) and smoking had moderate influence on a 
      minority of the parameters. CONCLUSIONS: We provide reference intervals for all 
      Sysmex XN analyzer routine, CPD and functional parameters, using a direct 
      approach in a large cohort in the Netherlands.
CI  - (c) 2022 Joost L. van Pelt et al., published by De Gruyter, Berlin/Boston.
FAU - L van Pelt, Joost
AU  - L van Pelt J
AD  - Department of Laboratory Medicine, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Klatte, Stefanie
AU  - Klatte S
AD  - Medical Science Department, Sysmex Europe GmbH, Norderstedt, Germany.
FAU - Hwandih, Talent
AU  - Hwandih T
AD  - Medical Science Department, Sysmex Europe GmbH, Norderstedt, Germany.
FAU - Barcaru, Andrei
AU  - Barcaru A
AD  - Department of Laboratory Medicine, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Riphagen, Ineke J
AU  - Riphagen IJ
AD  - Department of Laboratory Medicine, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Linssen, Jo
AU  - Linssen J
AD  - Medical Science Department, Sysmex Europe GmbH, Norderstedt, Germany.
FAU - Bakker, Stephan J L
AU  - Bakker SJL
AD  - Department of Internal Medicine, Division of Nephrology, University of Groningen, 
      University Medical Center Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Erythrocyte Count
MH  - *Erythrocyte Indices
MH  - Hematocrit
MH  - *Hematology/methods
MH  - Hemoglobins
MH  - Humans
MH  - Reference Values
OTO - NOTNLM
OT  - Sysmex XN analyzer
OT  - cell population data (CPD)
OT  - functional parameters
OT  - hematology
OT  - latent abnormal value exclusion (LAVE)
OT  - reference interval (RI)
EDAT- 2022/04/30 06:00
MHDA- 2022/05/14 06:00
CRDT- 2022/04/29 21:02
PHST- 2022/02/03 00:00 [received]
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/05/14 06:00 [medline]
PHST- 2022/04/29 21:02 [entrez]
AID - cclm-2022-0094 [pii]
AID - 10.1515/cclm-2022-0094 [doi]
PST - epublish
SO  - Clin Chem Lab Med. 2022 May 2;60(6):907-920. doi: 10.1515/cclm-2022-0094. Print 
      2022 May 25.