PMID- 35488073
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20221007
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 57
IP  - 7
DP  - 2022 Jul
TI  - Health-related quality of life in pediatric patients with beta-thalassemia major 
      after hematopoietic stem cell transplantation.
PG  - 1108-1115
LID - 10.1038/s41409-022-01663-0 [doi]
AB  - Our main purpose was to evaluate health-related quality of life (HRQOL) in 
      beta-thalassemia major patients who underwent transplantation from September 2012 to 
      November 2019. The PedsQL 4.0 scale proxy version was administered to 221 
      transplant patients aged 5-18 years. Their HRQOL results in the proxy-report were 
      compared with those in the proxy-report of 429 matched healthy peers and 198 
      matched nontransplant patients. Compared with their healthy peers, the transplant 
      patients exhibited worse HRQOL in the physical health domain (P < 0.001), school 
      domain (P < 0.001) and overall scores (P = 0.006). Patients within 4 years after 
      transplantation exhibited physical functioning (P < 0.001), school functioning 
      (P < 0.001) and overall HRQOL damage (P = 0.001); the scores across all domains 
      for patients more than 4 years after transplantation were not significantly 
      different from those for the healthy controls. The transplant patients rated 
      their HRQOL for all domains better than the nontransplant patients (P < 0.001). 
      The HRQOL of patients after human leukocyte antigen (HLA)-matched related and 
      HLA-matched unrelated donor transplantation were not significantly different. 
      Chronic graft-versus-host disease and two or more comorbidities were 
      independently negatively associated with overall HRQOL outcomes (P = 0.032 and 
      P < 0.001, respectively). In conclusion, patients more than 4 years after 
      transplantation achieve an HRQOL equal to that of their healthy peers.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Liang, Haiyan
AU  - Liang H
AUID- ORCID: 0000-0002-5220-4369
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Pan, Lin
AU  - Pan L
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Xie, Yanni
AU  - Xie Y
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Fan, Jing
AU  - Fan J
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Zhai, Lu
AU  - Zhai L
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Liang, Shaohua
AU  - Liang S
AD  - The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 
      Guangdong, 524002, PR China.
FAU - Zhang, Zhongming
AU  - Zhang Z
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China.
FAU - Lai, Yongrong
AU  - Lai Y
AUID- ORCID: 0000-0002-0371-1719
AD  - The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 
      530021, PR China. laiyongrong@263.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220429
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Child
MH  - *Graft vs Host Disease
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Quality of Life
MH  - *beta-Thalassemia/therapy
EDAT- 2022/04/30 06:00
MHDA- 2022/07/12 06:00
CRDT- 2022/04/29 23:26
PHST- 2021/12/02 00:00 [received]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/03/21 00:00 [revised]
PHST- 2022/04/30 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2022/04/29 23:26 [entrez]
AID - 10.1038/s41409-022-01663-0 [pii]
AID - 10.1038/s41409-022-01663-0 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2022 Jul;57(7):1108-1115. doi: 
      10.1038/s41409-022-01663-0. Epub 2022 Apr 29.