PMID- 35488339
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1476-7961 (Print)
IS  - 1476-7961 (Electronic)
IS  - 1476-7961 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Apr 29
TI  - Impact of oligomerization on the allergenicity of allergens.
PG  - 5
LID - 10.1186/s12948-022-00172-1 [doi]
LID - 5
AB  - Type I hypersensitivity (allergic reaction) is an unsuitable or overreactive 
      immune response to an allergen due to cross-link immunoglobulin E (IgE) 
      antibodies bound to its high-affinity IgE receptors (FcepsilonRIs) on effector cells. 
      It is needless to say that at least two epitopes on allergens are required to the 
      successful and effective cross-linking. There are some reports pointing to small 
      proteins with only one IgE epitope could cross-link FcepsilonRI-bound IgE through 
      homo-oligomerization which provides two same IgE epitopes. Therefore, 
      oligomerization of allergens plays an indisputable role in the allergenic feature 
      and stability of allergens. In this regard, we review the signaling capacity of 
      the B cell receptor (BCR) complex and cross-linking of FcepsilonRI which results in the 
      synthesis of allergen-specific IgE. This review also discusses the 
      protein-protein interactions involved in the oligomerization of allergens and 
      provide some explanations about the oligomerization of some well-known allergens, 
      such as calcium-binding allergens, Alt a 1, Bet v 1, Der p 1, Per a3, and Fel d 
      1, along with the effects of their concentrations on dimerization.
CI  - (c) 2022. The Author(s).
FAU - Hasan-Abad, Amin Moradi
AU  - Hasan-Abad AM
AD  - Autoimmune Diseases Research Center, Shahid Beheshti Hospital, Kashan University 
      of Medical Sciences, Kashan, Iran.
FAU - Mohammadi, Mohsen
AU  - Mohammadi M
AD  - Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical 
      Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, 
      Iran.
FAU - Mirzaei, Hamed
AU  - Mirzaei H
AD  - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute 
      for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
FAU - Mehrabi, Mohsen
AU  - Mehrabi M
AD  - Department of Medical Nanotechnology, School of Medicine, Shahroud University of 
      Medical Sciences, Shahroud, Iran.
FAU - Motedayyen, Hossein
AU  - Motedayyen H
AD  - Autoimmune Diseases Research Center, Shahid Beheshti Hospital, Kashan University 
      of Medical Sciences, Kashan, Iran. hmotedayyen@gmail.com.
FAU - Arefnezhad, Reza
AU  - Arefnezhad R
AD  - Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran. reza.aref1374@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220429
PL  - England
TA  - Clin Mol Allergy
JT  - Clinical and molecular allergy : CMA
JID - 101152195
PMC - PMC9052586
OTO - NOTNLM
OT  - Allergenicity
OT  - Cross-linking
OT  - High-affinity IgE receptor
OT  - Oligomerization
OT  - Protein-protein interactions
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/01 06:00
MHDA- 2022/05/01 06:01
PMCR- 2022/04/29
CRDT- 2022/04/30 00:01
PHST- 2022/02/16 00:00 [received]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/04/30 00:01 [entrez]
PHST- 2022/05/01 06:00 [pubmed]
PHST- 2022/05/01 06:01 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - 10.1186/s12948-022-00172-1 [pii]
AID - 172 [pii]
AID - 10.1186/s12948-022-00172-1 [doi]
PST - epublish
SO  - Clin Mol Allergy. 2022 Apr 29;20(1):5. doi: 10.1186/s12948-022-00172-1.