PMID- 35488492
OWN - NLM
STAT- MEDLINE
DCOM- 20220718
LR  - 20221222
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 29
IP  - 8
DP  - 2022 Aug
TI  - HLA-DRB1*03:01 is associated with female sex and younger age of anti-LGI1 
      encephalitis.
PG  - 2367-2375
LID - 10.1111/ene.15376 [doi]
AB  - BACKGROUND AND PURPOSE: This study was undertaken to investigate the association 
      between human leukocyte antigen (HLA) genotype and clinical characteristics of 
      anti-LGI1 encephalitis. METHODS: HLA genotyping was performed in 34 patients with 
      anti-LGI1 encephalitis admitted to West China Hospital between April 2014 and May 
      2021, as well as in 305 healthy controls. The online tool NetMHCIIpan 4.0 and 
      AutoDock Vina software were used to predict binding between LGI1 peptide and HLA 
      class II molecules. RESULTS: Risk of anti-LGI1 encephalitis was strongly 
      associated with the DRB1*03:01 allele (odds ratio [OR] = 4.31, 95% confidence 
      interval [CI] = 1.96-9.25, corrected p = 2.75 x 10(-4) ) and the 
      DRB1*03:01-DQB1*02:01 haplotype (OR = 4.45, 95% CI = 2.02-9.59, corrected 
      p = 2.94 x 10(-4) ). Compared to carriers of the DRB1*07:01 allele, those with 
      the DRB1*03:01 allele were more likely to be female (93.3% vs. 33.3%, p = 0.004) 
      and to be younger (median age = 38 vs. 65 years, p < 0.001). DRB1*03:01 carriers 
      showed stronger response to immunotherapy than carriers of the DRB1*07:01 allele, 
      based on median score decrease on the modified Rankin scale (2, interquartile 
      range = 1-2 vs. 1, interquartile range = 0-1; p = 0.03) at 4 weeks after 
      immunotherapy. Prediction and docking algorithms suggested that the LGI1 peptide 
      can bind to the DRB1*03:01 molecule strongly. CONCLUSIONS: The strong association 
      between anti-LGI1 encephalitis and certain HLA class II alleles supports a 
      primary autoimmune origin for the disease. Carriers of the DRB1*03:01 allele in 
      Chinese patients with anti-LGI1 encephalitis are more likely to be female, to 
      suffer earlier disease onset, and to respond better to immunotherapy.
CI  - (c) 2022 European Academy of Neurology.
FAU - Liu, Xu
AU  - Liu X
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Guo, Kun Dian
AU  - Guo KD
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Lin, Jingfang
AU  - Lin J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Gong, Xue
AU  - Gong X
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Li, Ai Qing
AU  - Li AQ
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Zhou, Dong
AU  - Zhou D
AUID- ORCID: 0000-0001-7101-4125
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Hong, Zhen
AU  - Hong Z
AUID- ORCID: 0000-0002-0014-6873
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
AD  - Institute of Brain Science and Brain-Inspired Technology, West China Hospital, 
      Sichuan University, Chengdu, China.
AD  - Department of Neurology, Chengdu Shangjin Nanfu Hospital, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220510
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (anti-leucine-rich glioma-inactivated 1 autoantibody)
RN  - Autoimmune limbic encephalitis
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Autoantibodies/blood
MH  - *Autoimmune Diseases/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
MH  - *Limbic Encephalitis/genetics
MH  - Male
MH  - Sex Factors
OTO - NOTNLM
OT  - anti-LGI1 encephalitis
OT  - human leukocyte antigen
EDAT- 2022/05/01 06:00
MHDA- 2022/07/19 06:00
CRDT- 2022/04/30 03:13
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/02/01 00:00 [received]
PHST- 2022/04/20 00:00 [accepted]
PHST- 2022/05/01 06:00 [pubmed]
PHST- 2022/07/19 06:00 [medline]
PHST- 2022/04/30 03:13 [entrez]
AID - 10.1111/ene.15376 [doi]
PST - ppublish
SO  - Eur J Neurol. 2022 Aug;29(8):2367-2375. doi: 10.1111/ene.15376. Epub 2022 May 10.