PMID- 35488503
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20221015
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Print)
IS  - 1043-3074 (Linking)
VI  - 44
IP  - 8
DP  - 2022 Aug
TI  - Laryngotracheal stenosis: Mechanistic review.
PG  - 1948-1960
LID - 10.1002/hed.27079 [doi]
AB  - BACKGROUND: The purpose of this review article is to summarize the existing 
      literature surrounding wound healing mechanisms in laryngotracheal stenosis. 
      METHODS: A review of general wound healing pathophysiology, followed by a focused 
      review of iatrogenic laryngotracheal stenosis (iLTS) and idiopathic subglottic 
      stenosis (iSGS) as conditions of aberrant wound healing. RESULTS: iLTS is the 
      scarring of the laryngotracheal complex, coming secondary to injury from 
      prolonged intubation. iSGS is a chronic fibroinflammatory scarring and narrowing 
      of the subglottic airway in the absence of any obvious preceding injury or 
      trauma. They are both thought to result from a prolonged and dysregulated wound 
      healing response that promotes the deposition of pathologic scar in the airway. 
      CONCLUSIONS: Understanding the mechanisms that underlie wound healing will help 
      identify and intervene on the process early in its development and discover 
      future therapies that target individual wound healing mechanisms limiting the 
      incidence of this recalcitrant disease process.
CI  - (c) 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.
FAU - Carpenter, Delaney J
AU  - Carpenter DJ
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Virginia 
      Health System, Charlottesville, Virginia, USA.
FAU - Hamdi, Osama A
AU  - Hamdi OA
AUID- ORCID: 0000-0002-3495-9231
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Virginia 
      Health System, Charlottesville, Virginia, USA.
FAU - Finberg, Ariel M
AU  - Finberg AM
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Virginia 
      Health System, Charlottesville, Virginia, USA.
FAU - Daniero, James J
AU  - Daniero JJ
AUID- ORCID: 0000-0003-3693-4617
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Virginia 
      Health System, Charlottesville, Virginia, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220430
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Cicatrix
MH  - Constriction, Pathologic/complications
MH  - Humans
MH  - *Laryngostenosis/etiology/pathology
MH  - *Tracheal Stenosis/etiology/therapy
PMC - PMC9543412
OTO - NOTNLM
OT  - LTS
OT  - airway
OT  - laryngotracheal stenosis
OT  - subglottic stenosis
OT  - wound healing
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2022/05/01 06:00
MHDA- 2022/07/08 06:00
PMCR- 2022/10/07
CRDT- 2022/04/30 03:32
PHST- 2022/04/19 00:00 [revised]
PHST- 2021/09/24 00:00 [received]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/01 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/04/30 03:32 [entrez]
PHST- 2022/10/07 00:00 [pmc-release]
AID - HED27079 [pii]
AID - 10.1002/hed.27079 [doi]
PST - ppublish
SO  - Head Neck. 2022 Aug;44(8):1948-1960. doi: 10.1002/hed.27079. Epub 2022 Apr 30.