PMID- 35488507
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20221018
IS  - 2398-9238 (Electronic)
IS  - 2398-9238 (Linking)
VI  - 5
IP  - 4
DP  - 2022 Jul
TI  - Diabetic kidney disease versus non-diabetic kidney disease in type 2 diabetic 
      patients on dialysis: An observational cohort.
PG  - e00281
LID - 10.1002/edm2.281 [doi]
LID - e00281
AB  - BACKGROUND: All chronic kidney diseases in diabetic patients are not diabetic 
      kidney diseases. The objective was to compare the clinical characteristics, 
      survival and access to transplantation in diabetic patients starting dialysis and 
      classified either as diabetic kidney disease (DKD) or non-diabetic kidney disease 
      in diabetic patients (NDKD). METHODS: We used the nationwide French REIN registry 
      to analyse baseline clinical characteristics at dialysis inception and outcomes 
      defined as kidney transplantation, deaths and their causes. The probability of 
      death or transplantation was analysed using a multivariate Cox model and the Fine 
      and Gray competing for risk model (sdHT). RESULTS: We included 65,136 patients 
      from January 2009 to December 2015 with a median follow-up of 31 months. The 
      cumulative incidence of kidney transplantation over eight years was 46.9% 
      (44.8-48.9) in non-diabetic patients (ND), higher than the 19.3% (17.5-21.2) in 
      the DKD group and 22.2% (18.4-26.7) in the NDKD group. The risk of death was 
      significantly higher in the NDKD group than in the DKD group, even after 
      accounting for the competing risk of transplantation (NDKD/sdHR 1.22; 95%CI 
      1.18-1.27; p < 0.005 vs. DKD/sdHR 1.12; 95%CI 1.08-1.16; p < 0.005 with 
      adjustment for age, sex, major adverse cardiovascular events, cancer and chronic 
      respiratory failure, compared to ND). CONCLUSIONS: In diabetic patients starting 
      dialysis, patients in the DKD group had reduced access to kidney transplantation. 
      NDKD patients had a higher risk of mortality than DKD. The distinction between 
      DKD and NDKD should be accounted for in the plan of care of diabetic patients 
      starting dialysis.
CI  - (c) 2022 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley 
      & Sons Ltd.
FAU - Delautre, Arnaud
AU  - Delautre A
AUID- ORCID: 0000-0001-8625-499X
AD  - Service de Nephrologie et Dialyse, Hopitaux Universitaires de Strasbourg, 
      Strasbourg, France.
AD  - Faculte de Medecine, Universite de Strasbourg, Strasbourg, France.
FAU - Hannedouche, Thierry
AU  - Hannedouche T
AD  - Service de Nephrologie et Dialyse, Hopitaux Universitaires de Strasbourg, 
      Strasbourg, France.
AD  - Faculte de Medecine, Universite de Strasbourg, Strasbourg, France.
FAU - Couchoud, Cecile
AU  - Couchoud C
AD  - Agence de Biomedecine, Paris, France.
FAU - Guiserix, Jose
AU  - Guiserix J
AD  - Centre Hospitalier Universitaire de La Reunion, Mayotte, France.
FAU - Cerasuolo, Damiano
AU  - Cerasuolo D
AD  - Centre Hospitalier de Caen, Caen, France.
FAU - Chantrel, Francois
AU  - Chantrel F
AD  - Service de Nephrologie, Centre Hospitalier Emile Muller de Mulhouse, Mulhouse, 
      France.
FAU - Martzloff, Jonas
AU  - Martzloff J
AD  - Service de Nephrologie et Dialyse, Hopitaux Universitaires de Strasbourg, 
      Strasbourg, France.
AD  - Faculte de Medecine, Universite de Strasbourg, Strasbourg, France.
FAU - Keller, Nicolas
AU  - Keller N
AD  - Service de Nephrologie et Dialyse, Hopitaux Universitaires de Strasbourg, 
      Strasbourg, France.
FAU - Krummel, Thierry
AU  - Krummel T
AD  - Service de Nephrologie et Dialyse, Hopitaux Universitaires de Strasbourg, 
      Strasbourg, France.
CN  - REIN registry
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220430
PL  - England
TA  - Endocrinol Diabetes Metab
JT  - Endocrinology, diabetes & metabolism
JID - 101732442
SB  - IM
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies/epidemiology/therapy
MH  - Humans
MH  - *Kidney Transplantation
MH  - Renal Dialysis
PMC - PMC9258992
OTO - NOTNLM
OT  - chronic kidney disease
OT  - diabetic kidney disease
OT  - mortality
OT  - transplantation
OT  - type 2 diabetes
COIS- The authors declared no conflict of interest in this work.
EDAT- 2022/05/01 06:00
MHDA- 2022/07/09 06:00
PMCR- 2022/04/30
CRDT- 2022/04/30 03:42
PHST- 2021/05/28 00:00 [revised]
PHST- 2021/03/23 00:00 [received]
PHST- 2021/05/30 00:00 [accepted]
PHST- 2022/05/01 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2022/04/30 03:42 [entrez]
PHST- 2022/04/30 00:00 [pmc-release]
AID - EDM2281 [pii]
AID - 10.1002/edm2.281 [doi]
PST - ppublish
SO  - Endocrinol Diabetes Metab. 2022 Jul;5(4):e00281. doi: 10.1002/edm2.281. Epub 2022 
      Apr 30.