PMID- 35489644
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220607
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 238
DP  - 2022 May
TI  - The expression pattern of membranous TNF-alpha is distinct from its intracellular 
      form in breast cancer-draining lymph nodes.
PG  - 109026
LID - S1521-6616(22)00107-3 [pii]
LID - 10.1016/j.clim.2022.109026 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is mostly known as a soluble cytokine. This 
      study, however, focused on its membranous form whose significance is rarely 
      investigated in antitumor immunity. Herein, we assessed the expression of both 
      membranous and intracellular forms of TNF-alpha (m/icTNF-alpha) in the lymphocytes 
      derived from breast cancer-draining lymph nodes. CD4(+)T cells were the main 
      subset expressing mTNF-alpha with the highest intensity, whereas icTNF-alpha expression 
      was most intense in CD8(+)T cells. An inverse correlation was seen between the 
      frequency of mTNF-alpha and the expression intensity of this cytokine in B cells. In 
      the clinical context, the higher intensity of mTNF-alpha expression in CD19(+) cells 
      correlated with poor prognosticators, while the frequency of mTNF-alpha(+)CD19(+) 
      cells showed a reverse correlation with the number of involved lymph nodes. The 
      two forms of TNF-alpha did not show similar associations with cancer parameters, 
      which highlights the complex role of this cytokine in breast cancer immunity.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ghods, Atri
AU  - Ghods A
AD  - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Mehdipour, Fereshteh
AU  - Mehdipour F
AD  - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of 
      Medical Sciences, Shiraz, Iran. Electronic address: mehdipourf@sums.ac.ir.
FAU - Rasolmali, Reza
AU  - Rasolmali R
AD  - Department of Pathology, Shiraz Central Hospital, Shiraz, Iran.
FAU - Talei, Abdol-Rasoul
AU  - Talei AR
AD  - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
FAU - Ghaderi, Abbas
AU  - Ghaderi A
AD  - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of 
      Medical Sciences, Shiraz, Iran; Department of Immunology, School of Medicine, 
      Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: 
      ghaderia@sums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20220427
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - B-Lymphocytes
MH  - *Breast Neoplasms
MH  - Female
MH  - Humans
MH  - Lymph Nodes
MH  - *Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Breast cancer
OT  - Lymphocyte
OT  - Membranous TNF-alpha
OT  - TNF-alpha
OT  - Tumor-draining lymph node
EDAT- 2022/05/01 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/04/30 19:27
PHST- 2021/09/01 00:00 [received]
PHST- 2022/03/02 00:00 [revised]
PHST- 2022/04/23 00:00 [accepted]
PHST- 2022/05/01 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/30 19:27 [entrez]
AID - S1521-6616(22)00107-3 [pii]
AID - 10.1016/j.clim.2022.109026 [doi]
PST - ppublish
SO  - Clin Immunol. 2022 May;238:109026. doi: 10.1016/j.clim.2022.109026. Epub 2022 Apr 
      27.