PMID- 35490266
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220503
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 21
IP  - 2
DP  - 2022 Apr 11
TI  - Study Effect of Azithromycin and Doxycycline in Mucus Producing and Inflammatory 
      Signaling Pathways of Allergic Asthma.
PG  - 119-127
LID - 10.18502/ijaai.v21i2.9220 [doi]
AB  - Asthma is a respiratory disease; involving millions of people worldwide. The main 
      cause of asthma is allergy and immune response dysregulation. The effects of 
      azithromycin and doxycycline as asthma-controlling drugs were evaluated in this 
      study. Mice asthma model was produced and asthmatic mice were treated with 
      azithromycin (75 mg/kg, orally) and doxycycline (20 mg/kg, orally). Eosinophils 
      and neutrophils count, interleukin (IL)-4, IL-5, IL-12, IL-13, and total 
      immunoglobulin E (IgE) levels were measured. Histological study and evaluating 
      the genes expression of Muc5ac, Muc5b, IL-33, COX2, MYD88, and TRAF6 were 
      performed. Azithromycin and doxycycline did not affect eosinophil and neutrophil 
      percentage, IL-4, IL-5, IL-12, and total IgE levels, peribronchial and 
      perivascular inflammation, goblet cell hyperplasia, and gene expression of MYD88, 
      TRAF6, and COX2. Treatment with azithromycin significantly decreased IL-13 level, 
      mucus secretion, and gene expression of IL-33, Muc5ac, and Muc5b; compared to the 
      non-treated asthma group. Azithromycin administration controls mucus secretion 
      and inflammation. Azithromycin therapy and not doxycycline might be an effective 
      adjuvant option in asthma with reducing mucus in the airway.
FAU - Wang, Zhen
AU  - Wang Z
AD  - The second Department of Respiration, Xi'an Children's Hospital, Xi'an, China. 
      Zhennwang@ymail.com.
FAU - Xin, Lihong
AU  - Xin L
AD  - The second Department of Respiration, Xi'an Children's Hospital, Xi'an, China. 
      Lihongnxin@ymail.com.
FAU - Zhang, Wen
AU  - Zhang W
AD  - The second Department of Respiration, Xi'an Children's Hospital, Xi'an, China. 
      wenzhang.res@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-33)
RN  - 0 (Interleukin-5)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 83905-01-5 (Azithromycin)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - N12000U13O (Doxycycline)
SB  - IM
MH  - Animals
MH  - *Asthma
MH  - *Azithromycin/pharmacology/therapeutic use
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Doxycycline/pharmacology/therapeutic use
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Inflammation/drug therapy
MH  - Interleukin-12
MH  - Interleukin-13/metabolism/therapeutic use
MH  - Interleukin-33
MH  - Interleukin-5/metabolism/therapeutic use
MH  - Mice
MH  - Mucus/metabolism
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - Signal Transduction
MH  - TNF Receptor-Associated Factor 6
OTO - NOTNLM
OT  - Allergy and immunology
OT  - Antibiotic prophylaxis
OT  - Inflammation
OT  - Signal transduction
EDAT- 2022/05/02 06:00
MHDA- 2022/05/04 06:00
CRDT- 2022/05/01 00:00
PHST- 2021/08/10 00:00 [received]
PHST- 2021/09/04 00:00 [accepted]
PHST- 2022/05/01 00:00 [entrez]
PHST- 2022/05/02 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
AID - 10.18502/ijaai.v21i2.9220 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):119-127. doi: 
      10.18502/ijaai.v21i2.9220.