PMID- 35490272
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220531
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 21
IP  - 2
DP  - 2022 Apr 11
TI  - The Role of HLA-DRB1 Alleles in Pulmonary Cystic Fibrosis.
PG  - 189-196
LID - 10.18502/ijaai.v21i2.9226 [doi]
AB  - Cystic fibrosis (CF) is the most common lethal autosomal recessive disease in 
      white Caucasians. It affects many organs including the lung, pancreas, and liver. 
      Whilst CF is a monogenic disease, several studies revealed a complex relationship 
      between genotype and clinical phenotype of diseases. We examined the expression 
      of human leukocyte antigen (HLA) class II alleles among Iranian CF patients with 
      disease-related microbial infection. This study was conducted on 50 hospitalized 
      CF patients (27 males, 23 females aged 15.5+/-6.5 years), and 50 healthy age- and 
      gender-matched control subjects. 5ml whole blood was harvested and after 
      isolation of genomic DNA, HLA-DRB1 subtypes were determined by single specific 
      primer polymerase chain reaction methods. HLA-DRB1*10 was less frequent and 
      HLA-DRB1*04 and HLA-DRB1*11 was the most frequent allele in CF patients, but none 
      reached significance. HLA-DRB1*04 allele was frequently seen among16 CF patients 
      with high serum IgE levels (430.25+/-219.7 IU/mL) and 27 CF patients that were 
      positive for Pseudomonas aeruginosa colonization. A total of 31 CF patients had 
      candida Albicans colonization in whom HLA-DRB1*11 was mostly seen. A total of 3 
      CF patients had allergic bronchopulmonary aspergillosis and two were diabetic. 
      The DR4 and DR11 serotypes that recognize the HLA-DRB1*04 and HLA-DRB1*11 gene 
      products respectively are not significantly enriched in the Iranian CF 
      population. Further research should be conducted on DR4 and DR11 in CF patients 
      to understand their possible role in infection and IgE expression.
FAU - Asef, Alireza
AU  - Asef A
AD  - Clinical Tuberculosis and Epidemiology Research Center, National Research 
      Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran. alireza.asef@yahoo.com.
FAU - Ghafaripour, Hossein Ali
AU  - Ghafaripour HA
AD  - Pediatric Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran. h.ghafaripour@gmail.com.
FAU - Jamaati, Hamidreza
AU  - Jamaati H
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran. hamidjamaati@hotmail.com.
FAU - Varahram, Mohammad
AU  - Varahram M
AD  - Clinical Tuberculosis and Epidemiology Research Center, National Research 
      Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran. mo.varahram@gmail.com.
FAU - M Adcock, Ian
AU  - M Adcock I
AD  - Cell and Molecular Biology Group, Airways Disease Section, National Heart and 
      Lung Institute, Imperial College London, London, UK AND Priority Research Centre 
      for Healthy Lungs, Hunter Medical Research Institute, The University of 
      Newcastle, Newcastle, New South Wales, Australia. ian.adcock@imperial.ac.uk.
FAU - Mortaz, Esmaeil
AU  - Mortaz E
AD  - Clinical Tuberculosis and Epidemiology Research Center, National Research 
      Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran AND Chronic Respiratory Diseases Research 
      Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran. emortaz@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HLA-DRB1 Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alleles
MH  - *Cystic Fibrosis/genetics
MH  - Female
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Immunoglobulin E
MH  - Iran
MH  - Male
OTO - NOTNLM
OT  - Cystic fibrosis
OT  - HLA-DRB1 chains
OT  - Pseudomonas aeruginosa
OT  - Staphylococcus aureus
EDAT- 2022/05/02 06:00
MHDA- 2022/05/04 06:00
CRDT- 2022/05/01 00:00
PHST- 2021/03/09 00:00 [received]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2022/05/01 00:00 [entrez]
PHST- 2022/05/02 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
AID - 10.18502/ijaai.v21i2.9226 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2022 Apr 11;21(2):189-196. doi: 
      10.18502/ijaai.v21i2.9226.