PMID- 35490470
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20220524
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 31
IP  - 7
DP  - 2022 Jul
TI  - A New Nomogram Model for Individualized Prediction of Cognitive Impairment in 
      Patients with Acute Ischemic Stroke.
PG  - 106515
LID - S1052-3057(22)00209-9 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2022.106515 [doi]
AB  - BACKGROUND: Cognitive impairment is a common symptom after ischemic stroke. Such 
      symptom can cause effect on rehabilitation of patients and their quality of life 
      and. As stroke rapidly growth on nowadays, a reliable scoring tool to detect the 
      risk of cognitive impairment after stroke is now being put on the first place. 
      METHODS: We enrolled patients with acute ischemic stroke (AIS) as samples and 
      hospitalized all at the First Affiliated Hospital of Soochow University between 
      October 2018 and June 2020. All patients were assessed by the Montreal Cognitive 
      Assessment (MoCA) scales and MoCA score < 26 was defined as standard to have 
      having cognitive impairment. All patients were randomly (7:3) divided into two 
      cohorts: the primary ones and the validated ones. Based on multivariate logistic 
      model, the independent predictors of cognitive impairment in the acute phase were 
      identified. The predictive nomogram was generated and evaluated by Harrell's 
      concordance index (C-index) and calibration plot both in two cohorts, 
      respectively. RESULTS: A total of 191 patients were enrolled, of whom 135 
      comprised the primary cohort and 56 comprised the validated cohort. Gender, age, 
      baseline NIHSS score, hyperhomocysteinemia (HHcy) and multiple lesions were 
      independently associated with acute cognitive impairment after stroke and 
      included to construct the nomogram. The nomogram derived from the primary cohort 
      had an Area Under Curve (AUC) of 0.773 and the validated ones had an AUC of 
      0.859. Calibration plot revealed adequate fit of the nomogram in predictive 
      value. CONCLUSION: The new nomogram based on gender, age, baseline NIHSS score, 
      HHcy and multiple lesions gave rise to an accurate and comprehensive prediction 
      for cognitive impairment in AIS patients. After further validation, it could 
      potentially be a reliable forecasting tool.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Tang, Anqi
AU  - Tang A
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Liu, Sanjiao
AU  - Liu S
AD  - Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei 
      University of Arts and Science, No. 136 Jingzhou Road, Xiangyang, Hubei 441000, 
      China.
FAU - Wang, Zhi
AU  - Wang Z
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Shao, Han
AU  - Shao H
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.899 Pinghai Road, Suzhou, Jiangsu 215006, China.
FAU - Cai, Xiuying
AU  - Cai X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.899 Pinghai Road, Suzhou, Jiangsu 215006, China. Electronic address: 
      cxy9990888@163.com.
FAU - Li, Tan
AU  - Li T
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.899 Pinghai Road, Suzhou, Jiangsu 215006, China. Electronic address: 
      504535473@qq.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220428
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - *Cognitive Dysfunction/complications/etiology
MH  - Humans
MH  - *Ischemic Stroke
MH  - Nomograms
MH  - Quality of Life
MH  - *Stroke/complications/diagnosis
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Ischemic stroke
OT  - Nomogram
OT  - Prediction
COIS- Declaration of Competing Interest No funding or grant support was received for 
      this manuscript, and the authors have no conflicts of interest to disclose.
EDAT- 2022/05/02 06:00
MHDA- 2022/05/25 06:00
CRDT- 2022/05/01 18:15
PHST- 2021/12/28 00:00 [received]
PHST- 2022/03/24 00:00 [revised]
PHST- 2022/04/11 00:00 [accepted]
PHST- 2022/05/02 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/05/01 18:15 [entrez]
AID - S1052-3057(22)00209-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2022.106515 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2022 Jul;31(7):106515. doi: 
      10.1016/j.jstrokecerebrovasdis.2022.106515. Epub 2022 Apr 28.