PMID- 35491659
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230115
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 33
IP  - 1
DP  - 2023 Jan
TI  - Impact of obstructive sleep apnea on the expression of inflammatory mediators in 
      diabetic macular edema.
PG  - 415-420
LID - 10.1177/11206721221099247 [doi]
AB  - PURPOSE: To determine differences in inflammatory markers expressed in diabetic 
      macular edema (DME) patients with and without obstructive sleep apnea (OSA). 
      METHODS: This was a prospective, cross-sectional study. Patients with treatment 
      naive DME were enrolled in the study. They were stratified into 2 groups based on 
      Apnea Hypopnea Index (AHI) from overnight polysomnography: OSA + (AHI >/= 15) and 
      OSA - (AHI<15). Multiplex immunoassay was performed for aqueous and serum 
      cytokines including VEGF, placental growth factor (PGF), ICAM, IL2, IL3, IL6, 
      IL8, IL10, IL17, vascular cell adhesion molecule-1 (VCAM1), monocyte attractant 
      protein-1 (MCP1), epidermal growth factor (EGF) and platelet derived growth 
      factor (PDGF). Statistical significance was defined as p < 0.004 using Bonferroni 
      correction. RESULTS: 32 DME positive patients were enrolled in the study; of 
      which 17 patients were OSA + and 15 OSA-. The OSA + cohort had significantly 
      higher levels of serum EGF (p = 0.003), and trended towards higher levels of most 
      serum cytokines including ICAM and IL6. OSA- cohort had significantly higher 
      levels of aqueous IL17 compared to the OSA + cohort (2.97 +/- 1.7 vs. 1.4 +/- 0.46 
      pg/mL, p = 0.004). There were no significant differences in other aqueous 
      cytokines. CONCLUSIONS: OSA + group trended towards higher levels of most serum 
      inflammatory markers, suggesting a greater pro-inflammatory state. However, they 
      did not have significantly greater level of aqueous cytokines.
FAU - Yang, Yelin
AU  - Yang Y
AUID- ORCID: 0000-0001-9932-8177
AD  - Department of Ophthalmology and Visual Sciences, 7938University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Somani, Sohel
AU  - Somani S
AUID- ORCID: 0000-0003-2547-3843
AD  - Department of Ophthalmology and Visual Sciences, 7938University of Toronto, 
      Toronto, Ontario, Canada.
AD  - Uptown Eye Specialists, Brampton, ON, Canada.
AD  - William Osler Health Systems, Brampton, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Interleukin-6)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 0 (Inflammation Mediators)
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Macular Edema/diagnosis/etiology
MH  - *Diabetic Retinopathy/diagnosis
MH  - Interleukin-6
MH  - Epidermal Growth Factor
MH  - Inflammation Mediators
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Placenta Growth Factor
MH  - Biomarkers
MH  - Cytokines
MH  - *Sleep Apnea, Obstructive/complications/diagnosis
MH  - *Diabetes Mellitus
PMC - PMC9834325
OTO - NOTNLM
OT  - Diabetic macular edema
OT  - cytokine
OT  - obstructive sleep apnea
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2022/05/03 06:00
MHDA- 2023/01/11 06:00
PMCR- 2023/01/12
CRDT- 2022/05/02 03:29
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/05/02 03:29 [entrez]
PHST- 2023/01/12 00:00 [pmc-release]
AID - 10.1177_11206721221099247 [pii]
AID - 10.1177/11206721221099247 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2023 Jan;33(1):415-420. doi: 10.1177/11206721221099247. Epub 
      2022 May 2.