PMID- 35492443
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 11
IP  - 62
DP  - 2021 Dec 6
TI  - 3-Methoxybutan-2-one as a sustainable bio-based alternative to chlorinated 
      solvents.
PG  - 39412-39419
LID - 10.1039/d1ra07322b [doi]
AB  - Methylation of acetoin with dimethyl carbonate was performed in a sustainable 
      one-step process, with improved process mass intensity (PMI) and atom economy 
      compared to previously published methods. The resulting product, 
      3-methoxybutan-2-one (MO) was successfully evaluated as a bio-based solvent, 
      while both Kamlet-Taft solvatochromic parameters and Hansen solubility parameters 
      demonstrate its potential viability in the substitution of chlorinated solvents. 
      MO exhibited a low peroxide forming potential and a negative Ames mutagenicity 
      test and was successfully used as a solvent in a Friedel-Crafts acylation (79% 
      yield compared to 77% in dichloromethane) and for N-alkylations. MO is a 
      renewable oxygenated solvent, with the potential ability to substitute 
      carcinogenic halogenated solvents in some applications.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Jin, Saimeng
AU  - Jin S
AUID- ORCID: 0000-0001-8056-2043
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - Byrne, Fergal P
AU  - Byrne FP
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - Clark, James H
AU  - Clark JH
AUID- ORCID: 0000-0002-5860-2480
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - McElroy, Con Robert
AU  - McElroy CR
AUID- ORCID: 0000-0003-2315-8153
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - Quinn, Alex
AU  - Quinn A
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - Sherwood, James
AU  - Sherwood J
AUID- ORCID: 0000-0001-5431-2032
AD  - Green Chemistry Centre of Excellence, Department of Chemistry, University of York 
      York YO10 5DD UK.
FAU - Hunt, Andrew J
AU  - Hunt AJ
AUID- ORCID: 0000-0003-3983-8313
AD  - Materials Chemistry Research Center, Department of Chemistry and Center of 
      Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University 
      Khon Kaen 40002 Thailand andrew@kku.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20211210
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9044657
COIS- There are no conflicts to declare.
EDAT- 2022/05/03 06:00
MHDA- 2022/05/03 06:01
PMCR- 2021/12/10
CRDT- 2022/05/02 06:10
PHST- 2021/10/01 00:00 [received]
PHST- 2021/11/23 00:00 [accepted]
PHST- 2022/05/02 06:10 [entrez]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/03 06:01 [medline]
PHST- 2021/12/10 00:00 [pmc-release]
AID - d1ra07322b [pii]
AID - 10.1039/d1ra07322b [doi]
PST - epublish
SO  - RSC Adv. 2021 Dec 10;11(62):39412-39419. doi: 10.1039/d1ra07322b. eCollection 
      2021 Dec 6.