PMID- 35493333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220503
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic 
      Targets.
PG  - 866700
LID - 10.3389/fnmol.2022.866700 [doi]
LID - 866700
AB  - Ischemic stroke (IS) is a cerebrovascular disease causing high rates of 
      disability and fatality. In recent years, the concept of the neurovascular unit 
      (NVU) has been accepted by an increasing number of researchers and is expected to 
      become a new paradigm for exploring the pathogenesis and treatment of IS. NVUs 
      are composed of neurons, endothelial cells, pericytes, astrocytes, microglia, and 
      the extracellular matrix. As an important part of the NVU, pericytes provide 
      support for other cellular components and perform a variety of functions, 
      including participating in the maintenance of the normal physiological function 
      of the blood-brain barrier, regulating blood flow, and playing a role in 
      inflammation, angiogenesis, and neurogenesis. Therefore, treatment strategies 
      targeting pericyte functions, regulating pericyte epigenetics, and transplanting 
      pericytes warrant exploration. In this review, we describe the reactions of 
      pericytes after IS, summarize the potential therapeutic targets and strategies 
      targeting pericytes for IS, and provide new treatment ideas for ischemic stroke.
CI  - Copyright (c) 2022 Zhou, Guo, Zhang, Qu and Jin.
FAU - Zhou, Sheng-Yu
AU  - Zhou SY
AD  - Department of Neurology, Stroke Center, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Guo, Zhen-Ni
AU  - Guo ZN
AD  - Clinical Trial and Research Center for Stroke, Department of Neurology, The First 
      Hospital of Jilin University, Changchun, China.
FAU - Zhang, Dian-Hui
AU  - Zhang DH
AD  - Department of Neurology, Stroke Center, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Qu, Yang
AU  - Qu Y
AD  - Department of Neurology, Stroke Center, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Jin, Hang
AU  - Jin H
AD  - Department of Neurology, Stroke Center, The First Hospital of Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220413
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC9043812
OTO - NOTNLM
OT  - brain-blood barrier
OT  - ischemic stroke
OT  - neurovascular unit
OT  - pericyte
OT  - therapeutic targets
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/03 06:00
MHDA- 2022/05/03 06:01
PMCR- 2022/01/01
CRDT- 2022/05/02 06:18
PHST- 2022/01/31 00:00 [received]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2022/05/02 06:18 [entrez]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/03 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.866700 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Apr 13;15:866700. doi: 10.3389/fnmol.2022.866700. 
      eCollection 2022.