PMID- 35493840
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220503
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - The First Case of Familiar Anti-leucine-rich Glioma-Inactivated1 Autoimmune 
      Encephalitis: A Case Report and Literature Review.
PG  - 855383
LID - 10.3389/fneur.2022.855383 [doi]
LID - 855383
AB  - Anti-leucine-rich glioma-inactivated1 (Anti-LGI1) autoimmune encephalitis is a 
      rare autoimmune disease discovered in recent years. It is generally not defined 
      as an inherited disease, though its etiology is still unclear. Herein, we report 
      the first case of adult patients with familial anti-LGI1 encephalitis. Two 
      biological siblings who worked in different regions were successively diagnosed 
      with anti-LGI1 encephalitis in their middle age. The two patients had similar 
      clinical manifestations including imaging results. Their clinical symptoms 
      improved after immunotherapy and antiepileptic therapy. Given that some unique 
      human leukocyte antigen (HLA) subtypes appear at a high frequency, multiple 
      recent studies have revealed that anti-LGI1 encephalitis is associated with 
      genetic susceptibility. One of the patients underwent HLA genotyping and 
      whole-exome sequencing (WES), revealing the same HLA typing as in previous 
      studies and two rare HLA variants. Therefore, further studies involving larger 
      samples and more populations should be conducted to explore the possibility of 
      other influencing factors such as environmental impacts.
CI  - Copyright (c) 2022 Ding, Sun, Li, Li and Wang.
FAU - Ding, Chuhan
AU  - Ding C
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Sun, Qibing
AU  - Sun Q
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Li, Ran
AU  - Li R
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Li, Hanli
AU  - Li H
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
LA  - eng
PT  - Case Reports
DEP - 20220414
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9047818
OTO - NOTNLM
OT  - Anti-leucine-rich glioma-inactivated1 autoimmune encephalitis
OT  - HLA
OT  - LGI1
OT  - autoimmune encephalitis
OT  - case report
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/03 06:00
MHDA- 2022/05/03 06:01
PMCR- 2022/04/14
CRDT- 2022/05/02 06:25
PHST- 2022/01/15 00:00 [received]
PHST- 2022/03/14 00:00 [accepted]
PHST- 2022/05/02 06:25 [entrez]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/03 06:01 [medline]
PHST- 2022/04/14 00:00 [pmc-release]
AID - 10.3389/fneur.2022.855383 [doi]
PST - epublish
SO  - Front Neurol. 2022 Apr 14;13:855383. doi: 10.3389/fneur.2022.855383. eCollection 
      2022.