PMID- 35495608
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220503
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 23
IP  - 6
DP  - 2022 Jun
TI  - Role of chemokines in early pregnancy loss.
PG  - 397
LID - 10.3892/etm.2022.11324 [doi]
LID - 397
AB  - The present study aimed to compare decidual protein levels and gene expression 
      levels of chemokines between patients with early pregnancy loss and those with 
      voluntary abortion. A total of 15 patients between 6 and 10 gestational weeks, 
      who presented with negative fetal heartbeat to the obstetrics and gynecology 
      outpatient clinics of Gaziosmanpasa Hospital (Yeni Yuzyil University, Istanbul, 
      Turkey) and who had no additional systemic disease and 13 patients between 6 and 
      10 gestational weeks, who presented with positive fetal heartbeat for voluntary 
      abortion were included in the present study. CX3CL1, CCL17, CXCR4, chemokine 
      ligand 12 (CXCL12) and intercellular adhesion molecule (ICAM)5 protein expression 
      levels were determined by ELISA and gene expression levels by reverse 
      transcription-quantitative PCR in fresh materials recovered after therapeutic 
      curettage. CX3CL1, CCL17, CXCR4, CXCL12 protein levels were significantly higher 
      and ICAM protein level was significantly lower in pregrant women with missed 
      abortion compared with those with voluntary abortion. While the amount of 
      increase in mean CX3CL1, CCL17, CXCR4 and CXCL12 gene expression levels in the 
      tissues of pregnant women with missed abortion was statistically higher than the 
      pregnant women who underwent voluntary abortion, the amount of increase in ICAM5 
      gene expression was found to be lower (P<0.001) in those with missed abortion. In 
      conclusion, the findings of the present study suggested that CCL17, CX3CL1, 
      CXCL12, CXCR4 and ICAM5 may be associated with missed abortion and may play an 
      important role in placental invasion and the continuation of pregnancy.
CI  - Copyright: (c) Gokce et al.
FAU - Gokce, Sefik
AU  - Gokce S
AD  - Department of Obstetrics and Gynecology, Gaziosmanpasa Hospital of Yeni Yuzyil 
      University, Istanbul 34245, Turkey.
FAU - Herkiloglu, Dilsad
AU  - Herkiloglu D
AD  - Department of Obstetrics and Gynecology, Gaziosmanpasa Hospital of Yeni Yuzyil 
      University, Istanbul 34245, Turkey.
FAU - Cevik, Ozge
AU  - Cevik O
AD  - Department of Biochemistry, School of Medicine, Aydin Adnan Menderes University, 
      Aydin 09010, Turkey.
FAU - Turan, Volkan
AU  - Turan V
AD  - Department of Obstetrics and Gynecology, School of Medicine, Health and 
      Technology University, Istanbul 34015, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220414
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC9047033
OTO - NOTNLM
OT  - CCL17
OT  - CX3CL1
OT  - CXCR4
OT  - chemokine ligand 12
OT  - intercellular adhesion molecule 5
OT  - missed abortion
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/03 06:00
MHDA- 2022/05/03 06:01
PMCR- 2022/04/14
CRDT- 2022/05/02 06:42
PHST- 2022/01/06 00:00 [received]
PHST- 2022/03/11 00:00 [accepted]
PHST- 2022/05/02 06:42 [entrez]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/03 06:01 [medline]
PHST- 2022/04/14 00:00 [pmc-release]
AID - ETM-23-6-11324 [pii]
AID - 10.3892/etm.2022.11324 [doi]
PST - ppublish
SO  - Exp Ther Med. 2022 Jun;23(6):397. doi: 10.3892/etm.2022.11324. Epub 2022 Apr 14.