PMID- 35496508
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220503
IS  - 1662-6567 (Print)
IS  - 1662-6567 (Electronic)
IS  - 1662-6567 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Jan-Apr
TI  - Amlodipine-Induced Subacute Cutaneous Lupus Erythematosus Localized to 
      Non-Sun-Exposed Areas.
PG  - 71-76
LID - 10.1159/000524001 [doi]
AB  - The cutaneous manifestations of subacute cutaneous lupus erythematosus (SCLE), a 
      subset of cutaneous lupus erythematosus, arise most often in sun-exposed areas. 
      We report a case of SCLE with atypical distribution, following treatment with 
      amlodipine. This highlighted a possible clue that can be used to clinically 
      distinguish a drug-induced case from an idiopathic disorder. A 92-year-old 
      Japanese woman presented with a 2-month history of progressive erythematous, 
      papulosquamous rash, and annular plaques in non-sun-exposed sites with no 
      systemic symptoms. Irbesartan/amlodipine besilate combination tablets were 
      prescribed 8 months earlier for hypertension. The appearance of the skin 
      eruptions, results of immunopathological findings, and temporal relationship 
      between the rash and drugs were suggestive of a diagnosis of drug-induced SCLE, 
      which was confirmed by the spontaneous resolution of these cutaneous eruptions 
      within 4 weeks after cessation of amlodipine treatment. The evaluation of 
      possible associations with medications should be performed in patients presenting 
      with clinical features characterizing SCLE in atypical sites (non-sun-exposed 
      areas).
CI  - Copyright (c) 2022 by S. Karger AG, Basel.
FAU - Mizuta, Takahiro
AU  - Mizuta T
AD  - Department of Dermatology, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, 
      Tokyo, Japan.
FAU - Kato, Miyuki
AU  - Kato M
AD  - Department of Dermatology, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, 
      Tokyo, Japan.
LA  - eng
PT  - Case Reports
DEP - 20220329
PL  - Switzerland
TA  - Case Rep Dermatol
JT  - Case reports in dermatology
JID - 101517685
PMC - PMC8995664
OTO - NOTNLM
OT  - Adverse drug reaction
OT  - Amlodipine
OT  - Calcium channel blocker
OT  - Case report
OT  - Subacute cutaneous lupus erythematosus
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/05/03 06:00
MHDA- 2022/05/03 06:01
PMCR- 2022/03/29
CRDT- 2022/05/02 06:51
PHST- 2021/11/03 00:00 [received]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/05/02 06:51 [entrez]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/03 06:01 [medline]
PHST- 2022/03/29 00:00 [pmc-release]
AID - cde-0014-0071 [pii]
AID - 10.1159/000524001 [doi]
PST - epublish
SO  - Case Rep Dermatol. 2022 Mar 29;14(1):71-76. doi: 10.1159/000524001. eCollection 
      2022 Jan-Apr.