PMID- 35498493
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 10
IP  - 24
DP  - 2020 Apr 6
TI  - High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA 
      nanostars against arterivirus and coronavirus.
PG  - 14161-14169
LID - 10.1039/d0ra01387k [doi]
AB  - Heparan sulfate (HS) is a kind of cellular adhesion receptor that mediates the 
      attachment and internalization of virus infection. Herein, to mimic the cell 
      surface receptor, mercaptoethane sulfonate (MES), an analogue of HS, was used as 
      the surface modifier to synthesize bovine serum albumin (BSA)-coated tellurium 
      nanoparticles (Te/BSA NPs) with a unique triangular star shape (Te/BSA 
      nanostars). Using porcine reproductive and respiratory syndrome virus (PRRSV), 
      which utilizes HS as a cellular receptor, as a model of arterivirus, we found 
      that Te/BSA nanostars suppressed virus infection mainly by inhibiting the virus 
      internalization process. Interestingly, Te/BSA nanostars exhibited much higher 
      antiviral activity than the spherical Te/BSA NPs (Te/BSA nanospheres), the Te/BSA 
      NPs were synthesized with GSH as a substitute of MES, suggesting that both MES 
      modification and the novel shapes of Te/BSA NPs enhance their antiviral activity. 
      Finally, the antiviral effect of Te/BSA nanostars on porcine epidemic diarrhea 
      virus (PEDV), a model of coronavirus, was also demonstrated, indicating the 
      potential broad-spectrum antiviral property of Te/BSA nanostars.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Zhou, Yanrong
AU  - Zhou Y
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Veterinary Medicine, Huazhong Agricultural University Wuhan 430070 P. 
      R. China.
AD  - The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070 P. 
      R. China.
FAU - Jiang, Xiaohan
AU  - Jiang X
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Science, Huazhong Agricultural University Wuhan 430070 P. R. China.
FAU - Tong, Ting
AU  - Tong T
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Science, Huazhong Agricultural University Wuhan 430070 P. R. China.
AD  - College of Resources and Environment, Huazhong Agricultural University Wuhan 
      430070 P. R. China.
FAU - Fang, Liurong
AU  - Fang L
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Veterinary Medicine, Huazhong Agricultural University Wuhan 430070 P. 
      R. China.
AD  - The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070 P. 
      R. China.
FAU - Wu, Yuan
AU  - Wu Y
AUID- ORCID: 0000-0002-6953-791X
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Science, Huazhong Agricultural University Wuhan 430070 P. R. China.
FAU - Liang, Jiangong
AU  - Liang J
AUID- ORCID: 0000-0002-8210-0210
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Science, Huazhong Agricultural University Wuhan 430070 P. R. China.
AD  - College of Resources and Environment, Huazhong Agricultural University Wuhan 
      430070 P. R. China.
FAU - Xiao, Shaobo
AU  - Xiao S
AUID- ORCID: 0000-0003-0023-9188
AD  - State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural 
      University Wuhan 430070 P. R. China liangjg@mail.hzau.edu.cn vet@mail.hzau.edu.cn 
      +86-27-8728-2608 +86-27-8728-6884.
AD  - College of Veterinary Medicine, Huazhong Agricultural University Wuhan 430070 P. 
      R. China.
AD  - The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070 P. 
      R. China.
LA  - eng
PT  - Journal Article
DEP - 20200407
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9051606
COIS- There are no conflicts to declare.
EDAT- 2020/04/07 00:00
MHDA- 2020/04/07 00:01
PMCR- 2020/04/07
CRDT- 2022/05/02 07:11
PHST- 2020/02/13 00:00 [received]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2022/05/02 07:11 [entrez]
PHST- 2020/04/07 00:00 [pubmed]
PHST- 2020/04/07 00:01 [medline]
PHST- 2020/04/07 00:00 [pmc-release]
AID - d0ra01387k [pii]
AID - 10.1039/d0ra01387k [doi]
PST - epublish
SO  - RSC Adv. 2020 Apr 7;10(24):14161-14169. doi: 10.1039/d0ra01387k. eCollection 2020 
      Apr 6.