PMID- 35499526
OWN - NLM
STAT- MEDLINE
DCOM- 20230503
LR  - 20230503
IS  - 1543-6136 (Electronic)
IS  - 1381-1118 (Linking)
VI  - 27
IP  - 2
DP  - 2023 Apr-Jun
TI  - Assessment of Plasma-Endogenous Opioid Neuropeptide Levels and Psychometric 
      Properties of Non-Suicidal Self-Injury in Adolescents.
PG  - 749-768
LID - 10.1080/13811118.2022.2066494 [doi]
AB  - OBJECTIVE: Non-suicidal self-injury (NSSI) is one of the most common mental 
      health problems and growing public-health issues, coupled with a significant 
      population-level burden among adolescents in both developed and developing 
      countries. We aimed to assess the role of endogenous opioid system-emotion 
      regulation circuitry in NSSI through measurement of plasma beta-endorphin (beta-EP), 
      met-enkephalin (MENK) levels, and determination of psychometric features of 
      Turkish adolescent subjects. METHOD: In this research, we measured plasma beta-EP 
      and MENK levels of 49 adolescents with NSSI and 39 control subjects without NSSI 
      between the ages of 12-18 years. All adolescent subjects were observed in the 
      outpatient clinic, and their clinical and sociodemographic characteristics were 
      examined. All subjects were assessed using the Brief Symptom Inventory (BSI) and 
      Inventory of Statements About Self Injury (ISAS). RESULTS: Plasma beta-EP levels 
      were statistically lower in adolescents with NSSI than control group, whereas 
      there was no statistically significant difference in MENK levels. beta-EP levels 
      showed a negative correlation with depression severity. The data obtained from 
      BSI and ISAS were not found to be associated with both beta-EP and MENK levels, 
      while subscale scores exhibited versatile correlations. CONCLUSION: Our findings 
      supported the salient role of beta-EP in NSSI behavior. Also, decreased plasma beta-EP 
      could be assessed as a reliable indicator for NSSI. However, it is possible that 
      measurement of basal plasma levels of neuropeptides might also bring many 
      confounders and could cause bias. Therefore, repeated measurements of 
      plasma-endogenous opioid neuropeptides in a time-dependent manner-concomitant to 
      engage of NSSI behavior-might give more reliable results.
FAU - Cakin Memik, Nursu
AU  - Cakin Memik N
AUID- ORCID: 0000-0001-9029-3457
FAU - Hunc, Fatih
AU  - Hunc F
AUID- ORCID: 0000-0001-6484-2432
FAU - Kalayci, Seyma
AU  - Kalayci S
AUID- ORCID: 0000-0002-1586-3306
FAU - Demir, Necmettin
AU  - Demir N
AUID- ORCID: 0000-0003-0538-1597
FAU - Senturk, Elif
AU  - Senturk E
AUID- ORCID: 0000-0003-3520-310X
FAU - Yildiz Gundogdu, Ozlem
AU  - Yildiz Gundogdu O
AUID- ORCID: 0000-0002-1303-1645
FAU - Ozlen Dillioglugil, Meltem
AU  - Ozlen Dillioglugil M
AUID- ORCID: 0000-0001-5349-6378
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220502
PL  - England
TA  - Arch Suicide Res
JT  - Archives of suicide research : official journal of the International Academy for 
      Suicide Research
JID - 9504451
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Neuropeptides)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - Child
MH  - Psychometrics
MH  - Analgesics, Opioid
MH  - *Self-Injurious Behavior/psychology
MH  - *Emotional Regulation
MH  - *Neuropeptides
OTO - NOTNLM
OT  - Adolescents
OT  - beta-endorphin
OT  - brief symptom inventory
OT  - inventory of statements about self-injury
OT  - non-suicidal self-injury
EDAT- 2022/05/03 06:00
MHDA- 2023/05/03 06:42
CRDT- 2022/05/02 11:23
PHST- 2023/05/03 06:42 [medline]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/05/02 11:23 [entrez]
AID - 10.1080/13811118.2022.2066494 [doi]
PST - ppublish
SO  - Arch Suicide Res. 2023 Apr-Jun;27(2):749-768. doi: 10.1080/13811118.2022.2066494. 
      Epub 2022 May 2.