PMID- 35499743
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20221004
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 37
IP  - 8
DP  - 2022 Oct
TI  - 180-W GreenLight laser photoselective vaporization with multiple triamcinolone 
      acetonide injections for the treatment of bladder neck contractures.
PG  - 3115-3121
LID - 10.1007/s10103-022-03568-2 [doi]
AB  - Bladder neck contracture (BNC), one of the most challenging complications after 
      transurethral resection of the prostate (TURP) and photoselective vaporization of 
      the prostate (PVP), lacks effective treatment. In the present study, our 
      experience in treating BNC using GreenLight laser vaporization with triamcinolone 
      acetonide (TA) injections was shared. This is a retrospective cohort study that 
      included 46 patients with BNC after TURP and PVP in our center. GreenLight laser 
      surgeries (180 W) were carried out and TA was administrated simultaneously. TA 
      injections were repeated every week for three times after surgeries. The 
      perioperative and postoperative parameters were reviewed and compared. Bladder 
      neck tissues were examined by immunohistochemical staining to explore the 
      expressions of collagen I, matrix metalloproteinase-3 (MMP-3), and transforming 
      growth factor-beta (TGF-beta) after treatments. The chief complaint symptoms of all 
      patients were significantly relieved after our treatments. None of them showed 
      BNC recurrence during the follow-up. Complications were rare and mild. 
      Postoperative assessments including maximal urinary flow rate (P < 0.01), 
      International Prostate Symptom Score (P < 0.01), quality of life index 
      (P < 0.01), and post-void residual volume (P < 0.001) were significantly better 
      than baseline values, respectively. Immunohistochemical staining showed 
      significantly lower expressions of collagen I (P < 0.001), MMP-3 (P < 0.001), and 
      TGF-beta (P < 0.001) after treatments. In conclusion, 180-W GreenLight laser with 
      repeated TA injections demonstrated the safety and long-term efficacy in treating 
      BNC, by inhibiting the expressions of fibrotic factors. Our procedure was a 
      promising treatment for BNC after PVP and TURP.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag London Ltd., 
      part of Springer Nature.
FAU - Sun, Xiaoliang
AU  - Sun X
AD  - Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, 250021, Shandong, China.
FAU - Jin, Xunbo
AU  - Jin X
AD  - Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, 250021, Shandong, China.
FAU - Leng, Kang
AU  - Leng K
AD  - Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, 250021, Shandong, China.
FAU - Zhao, Yong
AU  - Zhao Y
AD  - Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, 250021, Shandong, China.
FAU - Zhang, Haiyang
AU  - Zhang H
AUID- ORCID: 0000-0003-3790-4874
AD  - Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, 250021, Shandong, China. zhyhope77@163.com.
AD  - Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, 
      University of California, San Francisco, CA, 94143, USA. zhyhope77@163.com.
LA  - eng
GR  - 82070782/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220502
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 0 (Transforming Growth Factor beta)
RN  - 76057-06-2 (Transforming Growth Factors)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Collagen
MH  - *Contracture/drug therapy/etiology
MH  - Humans
MH  - *Laser Therapy/methods
MH  - Lasers
MH  - Male
MH  - Matrix Metalloproteinase 3
MH  - *Prostatic Hyperplasia/surgery
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Transforming Growth Factor beta
MH  - Transforming Growth Factors
MH  - *Transurethral Resection of Prostate/adverse effects
MH  - Treatment Outcome
MH  - Triamcinolone Acetonide/therapeutic use
MH  - Urinary Bladder/surgery
MH  - Volatilization
OTO - NOTNLM
OT  - Bladder neck contracture
OT  - GreenLight laser
OT  - Photoselective vaporization of prostate
OT  - Transurethral resection of prostate
OT  - Triamcinolone acetonide
EDAT- 2022/05/03 06:00
MHDA- 2022/10/05 06:00
CRDT- 2022/05/02 11:33
PHST- 2022/02/05 00:00 [received]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/03 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2022/05/02 11:33 [entrez]
AID - 10.1007/s10103-022-03568-2 [pii]
AID - 10.1007/s10103-022-03568-2 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2022 Oct;37(8):3115-3121. doi: 10.1007/s10103-022-03568-2. Epub 
      2022 May 2.