PMID- 35504204
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220621
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 109
DP  - 2022 Aug
TI  - The protective and therapeutic effects of 5-androstene3beta, 17beta-diol (ADIOL) in 
      abdominal post-operative adhesions in rat: Suppressing TLR4/NFkappaB/HMGB1/TGF1 beta/alpha 
      SMA pathway.
PG  - 108801
LID - S1567-5769(22)00285-5 [pii]
LID - 10.1016/j.intimp.2022.108801 [doi]
AB  - Neurosteroid, 5-androstenediol (ADIOL) had been experimentally applied to protect 
      against many diseases as it had anti-oxidant, anti-inflammatory, and 
      anti-apoptotic effects. In our study, we investigate its role in abdominal 
      postoperative adhesion (APA) formations. Our results demonstrate that ADIOL 
      alleviates APA formation after induction by cecal abrasion (CA) model in the male 
      rat. Interestingly, per administration of ADIOL before APA induction leads to 
      inhibit oxidative stress by increasing superoxide dismutase (SOD) and decreasing 
      Malondialdehyde (MAD) levels to a similar level to the sham group, in addition 
      inhibiting inflammatory pathway by decreasing toll-like receptor 4 (TLR4), 
      nuclear factor kappa-B (NFkappaB), and High mobility group box 1 (HMGB1) to a similar 
      level to the sham group, furthermore decreasing Transforming growth factor beta 1 
      (TGFbeta1) and alpha Smooth muscle -actin (alpha SMA) levels to similar levels in the 
      sham group. While administration of ADIOL after APA induction lead to decrease 
      adhesions formation by decreasing oxidative stress ( downward arrowMDA and  upward arrowSOD levels), 
      inflammatory markers ( downward arrowTLR4,  downward arrowNFkappaB, and  downward arrowHMGB1levels), and collagen deposition by 
      ( downward arrowTGF1 beta and downward arrowalpha SMA levels) is the highly significant manner to those levels in CA 
      model but also significant to those levels in the sham group. Concluded that, 
      pre-administration of ADIOL before APA induction was more effective than its 
      administration after adhesions formations.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Abbas, Noha A T
AU  - Abbas NAT
AD  - Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Egypt.
FAU - Hassan, Heba A
AU  - Hassan HA
AD  - Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Egypt. 
      Electronic address: HAHanafi@medicin.zu.edu.eg.
LA  - eng
PT  - Journal Article
DEP - 20220430
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Actins)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (HMGB1 Protein)
RN  - 0 (NF-kappa B)
RN  - 0 (Tlr4 protein, rat)
RN  - 0 (Toll-Like Receptor 4)
RN  - 95PS51EMXY (Androstenediol)
SB  - IM
MH  - Actins
MH  - *Androstenediol/pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - *HMGB1 Protein
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Rats
MH  - Tissue Adhesions/drug therapy/prevention & control
MH  - Toll-Like Receptor 4
OTO - NOTNLM
OT  - ADIOL
OT  - Abdominal postoperative adhesions
OT  - Inflammatory response
OT  - Oxidative stress
EDAT- 2022/05/04 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/03 18:23
PHST- 2022/01/20 00:00 [received]
PHST- 2022/04/17 00:00 [revised]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/04 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/03 18:23 [entrez]
AID - S1567-5769(22)00285-5 [pii]
AID - 10.1016/j.intimp.2022.108801 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2022 Aug;109:108801. doi: 10.1016/j.intimp.2022.108801. Epub 
      2022 Apr 30.