PMID- 35504340 OWN - NLM STAT- MEDLINE DCOM- 20220620 LR - 20240216 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 212 IP - Pt C DP - 2022 Sep TI - A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members. PG - 113367 LID - S0013-9351(22)00694-6 [pii] LID - 10.1016/j.envres.2022.113367 [doi] AB - BACKGROUND AND OBJECTIVES: Although polychlorinated biphenyls (PCBs) were banned decades ago, populations are continuously exposed to PCBs due to their persistence and bioaccumulation/biomagnification in the environment. Results from limited epidemiologic studies linking PCBs to thyroid cancer have been inconclusive. This study aimed to investigate the association between individual PCBs and PCB mixture and papillary thyroid cancer (PTC), the most common thyroid cancer histologic subtype. METHODS: We carried out a nested case-control study including 742 histologically confirmed PTC cases diagnosed in 2000-2013 and 742 individually matched controls among U.S. military service members. Pre-diagnostic serum samples that were collected on average nine years before PTC diagnosis were used to measure PCB congeners by gas chromatography isotope dilution high resolution mass spectrometry (GC/ID-HRMS). Conditional logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression were employed to estimate the association between single PCB congeners as well as their mixture and PTC. RESULTS: Four PCB congeners (PCB-74, PCB-99, PCB-105, PCB-118) had significant associations and dose-response relationships with increased risk of PTC in single congener models. When considering the effects from all measured PCBs and their potential interactions in the BKMR model, PCB-118 showed positive trends of association with PTC. Increased exposure to the PCB congeners as a mixturewas also associated with an increased risk of PTC in the WQS model, with the mixture dominated by PCB-118, followed by PCB-74 and PCB-99. One PCB congener, PCB-187, showed an inverse trend of association with PTC in the mixture analysis. DISCUSSION: This study suggests that exposure to certain PCBs as well as a mixture of PCBs were associated with an increased risk of PTC. The observed association was mainly driven by PCB-118, and to a lesser extent by PCB-74 and PCB-99. The findings warrant further investigation. CI - Published by Elsevier Inc. FAU - Zhuo, Haoran AU - Zhuo H AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA. FAU - Huang, Huang AU - Huang H AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA. FAU - Sjodin, Andreas AU - Sjodin A AD - Persistent Pollutants Biomonitoring Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Jin, Lan AU - Jin L AD - Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA. FAU - Ma, Shuangge AU - Ma S AD - Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. FAU - Denic-Roberts, Hristina AU - Denic-Roberts H AD - Oak Ridge Institute for Science and Education (ORISE), MD, USA; Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Department of Preventive Medicine & Biostatistics, Bethesda, MD, USA. FAU - Warren, Joshua L AU - Warren JL AD - Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. FAU - Jones, Richard AU - Jones R AD - Persistent Pollutants Biomonitoring Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Davis, Mark AU - Davis M AD - Persistent Pollutants Biomonitoring Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Sun, Peiyuan AU - Sun P AD - Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. FAU - Yu, Herbert AU - Yu H AD - Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA. FAU - Ward, Mary H AU - Ward MH AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. FAU - Udelsman, Robert AU - Udelsman R AD - Endocrine Neoplasia Institute, Miami Cancer Institute, Miami, FL, USA. FAU - Zhang, Yawei AU - Zhang Y AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA. FAU - Rusiecki, Jennifer A AU - Rusiecki JA AD - Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Department of Preventive Medicine & Biostatistics, Bethesda, MD, USA. Electronic address: jennifer.rusiecki@usuhs.edu. LA - eng GR - P30 CA016359/CA/NCI NIH HHS/United States GR - R01 ES020361/ES/NIEHS NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20220502 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Bayes Theorem MH - Case-Control Studies MH - *Environmental Pollutants/toxicity MH - Gas Chromatography-Mass Spectrometry MH - Humans MH - *Military Personnel MH - *Polychlorinated Biphenyls/toxicity MH - Thyroid Cancer, Papillary/chemically induced/epidemiology MH - *Thyroid Neoplasms/chemically induced/epidemiology PMC - PMC9238631 MID - NIHMS1805432 OTO - NOTNLM OT - Endocrine disrupting chemicals OT - Mixtures OT - PCBs OT - Papillary thyroid cancer OT - Persistent organic pollutants OT - Polychlorinated biphenyls COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/05/04 06:00 MHDA- 2022/06/22 06:00 PMCR- 2023/09/01 CRDT- 2022/05/03 19:23 PHST- 2021/10/21 00:00 [received] PHST- 2022/04/19 00:00 [revised] PHST- 2022/04/21 00:00 [accepted] PHST- 2022/05/04 06:00 [pubmed] PHST- 2022/06/22 06:00 [medline] PHST- 2022/05/03 19:23 [entrez] PHST- 2023/09/01 00:00 [pmc-release] AID - S0013-9351(22)00694-6 [pii] AID - 10.1016/j.envres.2022.113367 [doi] PST - ppublish SO - Environ Res. 2022 Sep;212(Pt C):113367. doi: 10.1016/j.envres.2022.113367. Epub 2022 May 2.