PMID- 35505209
OWN - NLM
STAT- MEDLINE
DCOM- 20220505
LR  - 20220524
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2432
DP  - 2022
TI  - DNA Methylation and Atopic Diseases.
PG  - 85-99
LID - 10.1007/978-1-0716-1994-0_7 [doi]
AB  - The prevalence of allergic diseases such as asthma is globally increasing, posing 
      threat to the life quality of the affected population. Genome-wide association 
      studies (GWAS) suggest that genetic variations only account for a small 
      proportion of immunoglobulin E (IgE)-mediated type I hypersensitivity. Recently, 
      epigenetics has gained attention as an approach to further understand the missing 
      heritability and underpinning mechanisms of allergic diseases. Furthermore, 
      epigenetic regulation allows the evaluation of the interaction between an 
      individual's genetic predisposition and their environmental exposures. This 
      chapter summarizes several large-scale epigenome-wide association studies (EWAS) 
      on asthma and other allergic diseases and draws a blueprint for future analysis 
      and research direction.
CI  - (c) 2022. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Jiang, Yale
AU  - Jiang Y
AD  - Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's 
      Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
AD  - School of Medicine, Tsinghua University, Beijing, China.
FAU - Forno, Erick
AU  - Forno E
AD  - Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's 
      Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Chen, Wei
AU  - Chen W
AD  - Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's 
      Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. 
      wec47@pitt.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - *Asthma/genetics
MH  - DNA Methylation
MH  - Epigenesis, Genetic
MH  - Epigenome
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Hypersensitivity/genetics
OTO - NOTNLM
OT  - Allergy
OT  - Asthma
OT  - Atopy
OT  - DNA methylation
OT  - IgE
EDAT- 2022/05/04 06:00
MHDA- 2022/05/06 06:00
CRDT- 2022/05/03 23:30
PHST- 2022/05/03 23:30 [entrez]
PHST- 2022/05/04 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
AID - 10.1007/978-1-0716-1994-0_7 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2022;2432:85-99. doi: 10.1007/978-1-0716-1994-0_7.