PMID- 35506912
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 31
IP  - 5
DP  - 2023 Aug
TI  - High-grade Endometrial Stromal Sarcoma: Morphologic and Clinical Features, the 
      Role of Immunohistochemistry and Fluorescence in Situ Hybridization in Diagnosis.
PG  - 521-531
LID - 10.1177/10668969221098087 [doi]
AB  - Introduction. High-grade endometrial stromal sarcomas (HGESS) are rare malignant 
      mesenchymal tumors of the uterus with aggressive poor clinical outcome, which 
      frequently exhibit YWHAE::NUTM2 and ZC3H7B::BCOR fusions. In this study, we aimed 
      to investigate HGESSs with YWHAE and BCOR translocations through our archive 
      materials, and to identify morphological, immunohistochemical and molecular 
      features of these tumors. We also assessed the diagnostic value of BCOR 
      immunohistochemistry (IHC) in HGESSs, low-grade endometrial stromal sarcomas 
      (LGESS) and uterine leiomyosarcomas. Methods. One hundred fifty-one uterine 
      sarcomas diagnosed between 2000-2019 were reevaluated, and tumors of 39 patients 
      with specific features were included in the study. Fluorescence in situ 
      hybridization (FISH) studies using YWHAE and BCOR break-apart probes and BCOR IHC 
      were performed. BCOR IHC was also performed in 20 leiomyosarcomas and 19 LGESSs. 
      Results. In six HGESSs, translocations involving YWHAE or BCOR were detected. 
      Five tumors showed high-grade morphology and revealed YWHAE translocation. One 
      HGESS with myxoid morphology revealed BCOR translocation. In 
      immunohistochemistry, three (3/4) YWHAE translocated HGESSs showed BCOR 
      expression. However, the BCOR translocated HGESS was BCOR negative. The study 
      showed that all LGESSs were immunohistochemically negative with BCOR. Although 
      15% (3/20) leiomyosarcomas reveal focal weak-moderate BCOR expression. 
      Conclusion. BCOR IHC is a useful marker to distinguish LGESS from HGESS. A small 
      percentage of uterine leiomyosarcomas reveal BCOR expression; however, it is not 
      as diffuse and strong as in HGESSs. Strong and diffuse BCOR IHC expression is 
      highly suggestive for HGESS. The diagnosis of HGESS should be supported by 
      molecular studies such as FISH.
FAU - Alkanat, Nazli Eylem
AU  - Alkanat NE
AUID- ORCID: 0000-0003-3506-3856
AD  - Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, 
      Turkey. RINGGOLD: 37515
FAU - Uner, Aysegul
AU  - Uner A
AD  - Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, 
      Turkey. RINGGOLD: 37515
FAU - Usubutun, Alp
AU  - Usubutun A
AD  - Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, 
      Turkey. RINGGOLD: 37515
LA  - eng
PT  - Journal Article
DEP - 20220504
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
SB  - IM
MH  - Female
MH  - Humans
MH  - *Endometrial Neoplasms/diagnosis/genetics/metabolism
MH  - *Sarcoma, Endometrial Stromal/diagnosis/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Immunohistochemistry
MH  - *Leiomyosarcoma
MH  - *Uterine Neoplasms/diagnosis/genetics
MH  - *Sarcoma
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - BCOR
OT  - YWHAE
OT  - cyclinD1
OT  - endometrial stromal sarcoma
OT  - uterine mesenchymal tumor
EDAT- 2022/05/05 06:00
MHDA- 2023/07/03 06:41
CRDT- 2022/05/04 10:24
PHST- 2023/07/03 06:41 [medline]
PHST- 2022/05/05 06:00 [pubmed]
PHST- 2022/05/04 10:24 [entrez]
AID - 10.1177/10668969221098087 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2023 Aug;31(5):521-531. doi: 10.1177/10668969221098087. Epub 
      2022 May 4.