PMID- 35507233
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20220711
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 40
IP  - 4
DP  - 2022 Aug
TI  - The Combined Effects of Perinatal Ethanol and Early-Life Stress on Cognition and 
      Risk-Taking Behavior through Oxidative Stress in Rats.
PG  - 925-940
LID - 10.1007/s12640-022-00506-6 [doi]
AB  - Both prenatal ethanol and early-life stress have been shown to induce reduced 
      risk-taking and explorative behavior as well as cognitive dysfunction in the 
      offspring. In this study, we examined the effect of combined exposure to ethanol 
      and early stress on maternal care, exploratory behavior, memory performances, and 
      oxidative stress in male offspring. Pregnant rats were exposed to ethanol 
      (4 g/kg) from gestational day (GD) 6-to postnatal day (PND) 14 and limited 
      nesting material (LNS) from PND0-PND14 individually or in combination. Maternal 
      behavior was evaluated during diurnal cycle. The level of corticosterone hormone 
      and markers of oxidative stress were evaluated in the pups. Risk-taking and 
      explorative behavior were assessed with the elevated-plus maze (EPM) test and 
      cognitive behavior with the Morris water maze (MWM), novel object recognition 
      (NORT), and object location memory (OLM) tests. In the mothers, perinatal alcohol 
      or LNS either alone or in combination decreased maternal behavior. In the 
      offspring, the combination of the two factors significantly increased the pup's 
      plasma corticosterone concentration in comparison with ethanol and LNS alone. 
      Reduced risk-taking behavior was observed in the ethanol, LNS and ethanol + LNS 
      groups compared with the control group, and this was amplified in the co-exposure 
      of ethanol and LNS groups. The MWM, NORT, and OLM tests revealed spatial and 
      recognition memory impairment in the ethanol and LNS groups. This impairment was 
      more profound in the co-exposure of ethanol and LNS. Also, we observed a 
      significant decrease in superoxide dismutase (SOD) and glutathione peroxidase 
      (GPx) activities and an increase in malondialdehyde (MDA) level in the 
      hippocampus of ethanol and LNS co-exposed animals as compared with individual 
      exposure of ethanol and LNS. While each factor independently produced similar 
      outcomes, the results indicate that the dual exposure paradigm could 
      significantly strengthen the outcomes.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Bagheri, Farzaneh
AU  - Bagheri F
AD  - School of Biology, Damghan University, Damghan, Iran.
FAU - Goudarzi, Iran
AU  - Goudarzi I
AUID- ORCID: 0000-0002-6665-3202
AD  - School of Biology, Damghan University, Damghan, Iran. irangoudarzi@du.ac.ir.
FAU - Lashkarbolouki, Taghi
AU  - Lashkarbolouki T
AD  - School of Biology, Damghan University, Damghan, Iran.
FAU - Elahdadi Salmani, Mahmoud
AU  - Elahdadi Salmani M
AD  - School of Biology, Damghan University, Damghan, Iran.
FAU - Goudarzi, Afsaneh
AU  - Goudarzi A
AD  - Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Morley-Fletcher, Sara
AU  - Morley-Fletcher S
AD  - UMR 8576, Univ. Lille, CNRS, UGSF - Unite de Glycobiologie Structurale Et 
      Fonctionnelle, 59000, Lille, France.
LA  - eng
PT  - Journal Article
DEP - 20220504
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Antioxidants)
RN  - 3K9958V90M (Ethanol)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - *Adverse Childhood Experiences
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Cognition
MH  - Corticosterone
MH  - Ethanol/toxicity
MH  - Female
MH  - Hippocampus
MH  - Humans
MH  - Male
MH  - Maze Learning
MH  - Oxidative Stress
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Rats
MH  - Rats, Wistar
MH  - Risk-Taking
OTO - NOTNLM
OT  - Anxiety
OT  - Early-life stress
OT  - Ethanol
OT  - Learning and memory
OT  - Oxidative stress
OT  - Rat offspring
EDAT- 2022/05/05 06:00
MHDA- 2022/07/12 06:00
CRDT- 2022/05/04 11:21
PHST- 2021/08/19 00:00 [received]
PHST- 2022/04/09 00:00 [accepted]
PHST- 2022/04/07 00:00 [revised]
PHST- 2022/05/05 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2022/05/04 11:21 [entrez]
AID - 10.1007/s12640-022-00506-6 [pii]
AID - 10.1007/s12640-022-00506-6 [doi]
PST - ppublish
SO  - Neurotox Res. 2022 Aug;40(4):925-940. doi: 10.1007/s12640-022-00506-6. Epub 2022 
      May 4.