PMID- 35507337
OWN - NLM
STAT- MEDLINE
DCOM- 20230421
LR  - 20230421
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 26
IP  - 6
DP  - 2023 Jun
TI  - The potential of curcumin for treating spinal cord injury: a meta-analysis study.
PG  - 560-571
LID - 10.1080/1028415X.2022.2070703 [doi]
AB  - INTRODUCTION: In this paper, we conducted a meta-analysis on the curcumin effect 
      on functional recovery provided by the Basso, Beattie, Brenham (BBB) test for 
      rats, and the Basso mouse scale (BMS) for mice after spinal cord injury (SCI) in 
      animal models. METHOD: Data mining was performed, and the standard mean 
      difference (SMD) between the treated and control (untreated) groups was 
      calculated using the STATA software. Quality control and subgroup analysis were 
      performed. RESULTS: The analysis includes 24 experimental studies that showed 
      curcumin had a strong significance in improving functional recovery after SCI 
      (SMD = 3.38; 95% CI: 2.54-4.22; p < 0.001). When curcumin was administered daily, 
      it had a stronger effect than single-dose treatment or weekly administration. 
      Despite the same effect in the follow-up time before and after 4 weeks 
      post-injury, but later 9 weeks, curcumin had only a moderate effect. Curcumin 
      also significantly reduced the expression of GFAP (Glial fibrillary acidic 
      protein) marker compared to untreated groups. CONCLUSION: These findings suggest 
      that daily administration of curcumin can be an effective approach to improving 
      functional recovery after SCI.
FAU - Kahuripour, Mahnaz
AU  - Kahuripour M
AD  - Department of Medical Nanotechnology, Faculty of Advanced Technologies in 
      Medicine, Iran University of Medical Sciences, Tehran, Iran.
FAU - Behroozi, Zahra
AU  - Behroozi Z
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran.
AD  - Department of Physiology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Rahimi, Behnaz
AU  - Rahimi B
AD  - Department of Physiology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Hamblin, Michael R
AU  - Hamblin MR
AD  - Laser Research Centre, Faculty of Health Science, University of Johannesburg, 
      Doornfontein, South Africa.
FAU - Ramezani, Fatemeh
AU  - Ramezani F
AD  - Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220504
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Rats
MH  - Mice
MH  - Animals
MH  - *Curcumin/therapeutic use
MH  - Rats, Sprague-Dawley
MH  - *Spinal Cord Injuries/drug therapy
MH  - Disease Models, Animal
MH  - Recovery of Function
MH  - Spinal Cord/metabolism
OTO - NOTNLM
OT  - Curcumin
OT  - GFAP (Glial fibrillary acidic protein)
OT  - animal
OT  - functional recovery
OT  - meta analysis
OT  - regenerative disorder
OT  - spinal cord injury
OT  - turmeric
EDAT- 2022/05/05 06:00
MHDA- 2023/04/21 06:41
CRDT- 2022/05/04 11:33
PHST- 2023/04/21 06:41 [medline]
PHST- 2022/05/05 06:00 [pubmed]
PHST- 2022/05/04 11:33 [entrez]
AID - 10.1080/1028415X.2022.2070703 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2023 Jun;26(6):560-571. doi: 10.1080/1028415X.2022.2070703. Epub 
      2022 May 4.