PMID- 35507903
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220506
IS  - 1559-2863 (Electronic)
IS  - 0361-7734 (Linking)
VI  - 46
IP  - 6
DP  - 2021 Nov 1
TI  - Effect Of Calcium Silicate, Sodium Phosphate, and Fluoride on Dentinal Tubule 
      Occlusion and Permeability in Comparison to Desensitizing Toothpaste: An In Vitro 
      Study.
PG  - 641-649
LID - 10.2341/20-008-L [doi]
AB  - This study compared the ability of a calcium silicate-, sodium phosphate-, and 
      fluoride-based (CSSPF) toothpaste (TP) in promoting dentinal tubule occlusion and 
      reducing dentin permeability with that of other commercially available 
      antisensitivity TPs. Seventy-eight dentin discs (1.0+/-0.1 mm thick) were prepared 
      from the midcoronal area and were treated with 37% phosphoric acid for 2 minutes; 
      then they were randomly divided into six groups according to treatments: No 
      treatment [positive control (PC)], entirely covered with nail varnish [negative 
      control (NC)], hydroxyapatite (HAP)-containing TP [Desensin Repair (DES)], 
      NovaMin-based [Sensodyne Repair & Protect (SEN)], CSSPF-based TP [Regenerate 
      Advanced (REG)], sodium monofluorophosphate, potassium citrate, zinc citrate TP 
      [Signal Sensitive Expert (SIG)]. Dentin permeability was tested by the dye 
      percolation method (DP%). Scanning electron microscope (SEM) micromorphological 
      and energy dispersive X-ray elemental analysis (EDX) of the dentin surfaces were 
      done following each treatment. Results were analyzed using one-way analysis of 
      variance (ANOVA) followed by Tukey post hoc test at a 95% confidence level 
      (alpha=0.05). All the tested groups showed higher DP% than NC and lower percolation 
      than the PC (p<0.05). REG and SIG were statistically comparable, and showed 
      significantly lower DP% (p<0.05) than SEN and DES. None of the TPs tested was 
      able to obliterate the lumen of the dentinal tubules (DT) completely. REG 
      exhibited the highest weight percentage of calcium deposition, followed by SEN. 
      Compared to the tested desensitizing TPs, CSSPF-based TPs demonstrated equal or 
      less dentin permeability and better DT occlusion.
CI  - (c)Operative Dentistry, 2021.
FAU - Rahman, B
AU  - Rahman B
AD  - Betul Rahman, associate professor, Department of Preventive and Restorative 
      Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.
FAU - El-Damanhoury, H M
AU  - El-Damanhoury HM
AD  - *Hatem M El-Damanhoury, associate professor, Department of Preventive and 
      Restorative Dentistry, College of Dental Medicine, University of Sharjah, 
      Sharjah, UAE.
FAU - Sheela, S
AU  - Sheela S
AD  - Soumya Sheela, post-doctoral research associate, Sharjah Institute of Medical 
      Research, University of Sharjah, Sharjah, UAE.
FAU - Ngo, H C
AU  - Ngo HC
AD  - Hien C Ngo, professor, Department of Preventive and Restorative Dentistry, 
      College of Dental Medicine, University of Sharjah, Sharjah, UAE.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oper Dent
JT  - Operative dentistry
JID - 7605679
RN  - 0 (Calcium Compounds)
RN  - 0 (Dentin Desensitizing Agents)
RN  - 0 (Phosphates)
RN  - 0 (Silicates)
RN  - 0 (Toothpastes)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - Q80VPU408O (Fluorides)
RN  - S4255P4G5M (calcium silicate)
RN  - SE337SVY37 (sodium phosphate)
MH  - Calcium Compounds
MH  - Dentin
MH  - *Dentin Desensitizing Agents/pharmacology/therapeutic use
MH  - Dentin Permeability
MH  - *Dentin Sensitivity/drug therapy
MH  - Fluorides/pharmacology/therapeutic use
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Permeability
MH  - Phosphates
MH  - Silicates
MH  - Sodium Fluoride
MH  - Toothpastes/pharmacology
EDAT- 2022/05/05 06:00
MHDA- 2022/05/07 06:00
CRDT- 2022/05/04 16:12
PHST- 2020/11/27 00:00 [accepted]
PHST- 2022/05/04 16:12 [entrez]
PHST- 2022/05/05 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
AID - 481123 [pii]
AID - 10.2341/20-008-L [doi]
PST - ppublish
SO  - Oper Dent. 2021 Nov 1;46(6):641-649. doi: 10.2341/20-008-L.