PMID- 35508592
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220924
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 May 4
TI  - Immunogenetic clustering of 30 cancers.
PG  - 7235
LID - 10.1038/s41598-022-11366-7 [doi]
LID - 7235
AB  - Human leukocyte antigen (HLA) genes have been implicated in cancer risk and 
      shared heritability of different types of cancer. In this immunogenetic 
      epidemiological study we first computed a Cancer-HLA profile for 30 cancer types 
      characterized by the correlation between the prevalence of each cancer and the 
      population frequency of 127 HLA alleles, and then used multidimensional scaling 
      to evaluate the possible clustering of those Cancer-HLA associations. The results 
      indicated the presence of three clusters, broadly reflecting 
      digestive-skin-cervical cancers, reproductive and endocrine systems cancers, and 
      brain and androgen-associated cancers. The clustering of cancer types documented 
      here is discussed in terms of mechanisms underlying shared Cancer-HLA 
      associations.
CI  - (c) 2022. The Author(s).
FAU - James, Lisa M
AU  - James LM
AD  - The HLA Research Group, Brain Sciences Center (11B), Department of Veterans 
      Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, 
      MN, 55417, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AD  - The HLA Research Group, Brain Sciences Center (11B), Department of Veterans 
      Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, 
      MN, 55417, USA. omega@umn.edu.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. omega@umn.edu.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. omega@umn.edu.
AD  - Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 
      55455, USA. omega@umn.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220504
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Cluster Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - *Immunogenetics
MH  - *Uterine Cervical Neoplasms/genetics
PMC - PMC9068692
COIS- The authors declare no competing interests.
EDAT- 2022/05/05 06:00
MHDA- 2022/05/07 06:00
PMCR- 2022/05/04
CRDT- 2022/05/04 23:44
PHST- 2022/01/27 00:00 [received]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/05/04 23:44 [entrez]
PHST- 2022/05/05 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
PHST- 2022/05/04 00:00 [pmc-release]
AID - 10.1038/s41598-022-11366-7 [pii]
AID - 11366 [pii]
AID - 10.1038/s41598-022-11366-7 [doi]
PST - epublish
SO  - Sci Rep. 2022 May 4;12(1):7235. doi: 10.1038/s41598-022-11366-7.