PMID- 35510700
OWN - NLM
STAT- MEDLINE
DCOM- 20220520
LR  - 20220520
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 14
IP  - 19
DP  - 2022 May 19
TI  - Doxorubicin delivery performance of superparamagnetic carbon multi-core shell 
      nanoparticles: pH dependence, stability and kinetic insight.
PG  - 7220-7232
LID - 10.1039/d1nr08550f [doi]
AB  - In the past decade, magnetic nanoparticles (MNPs) have been among the most 
      attractive nanomaterials used in different fields, such as environmental and 
      biomedical applications. The possibility of designing nanoparticles with 
      different functionalities allows for advancing the biomedical applications of 
      these materials. Additionally, the magnetic characteristics of the nanoparticles 
      enable the use of magnetic fields to drive the nanoparticles to the desired sites 
      of delivery. In this context, the development of new MNPs in new approaches for 
      drug delivery systems (DDSs) for cancer treatment has increased. However, the 
      synthesis of nanoparticles with high colloidal stability triggered drug delivery, 
      and good biocompatibility remains a challenge. Herein, multi-core shell MNPs 
      functionalized with Pluronic (R) F-127 were prepared and thoroughly characterized 
      as drug carriers for doxorubicin delivery. The functionalized nanoparticles have 
      an average size of 17.71 +/- 4.2 nm, high water colloidal stability, and 
      superparamagnetic behavior. In addition, the nanoparticles were able to load 936 
      mug of DOX per mg of functionalized nanomaterial. Drug release studies at 
      different pH values evidenced a pH-triggered DOX release effect. An increase of 
      62% in cumulative drug release was observed at pH simulating tumor 
      endosome/lysosome microenvironments (pH 4.5) compared to physiological conditions 
      (pH 7.4). In addition, an innovative dynamic drug delivery study was performed as 
      a function of pH. The results from this test confirmed the pH-induced doxorubicin 
      release capability of carbon multi-core shell MNPs. The validity of traditional 
      kinetic models to fit dynamic pH-dependent drug release was also studied for 
      predictive purposes.
FAU - Silva, Adriano Santos
AU  - Silva AS
AUID- ORCID: 0000-0002-6795-2335
AD  - Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, 
      Campus Santa Apolonia, 5300-253, Braganca, Portugal.
FAU - Diaz de Tuesta, Jose Luis
AU  - Diaz de Tuesta JL
AUID- ORCID: 0000-0003-2408-087X
AD  - Universidade Tecnologica Federal do Parana, Campus Ponta Grossa, 84017-220, Ponta 
      Grossa, Parana, Brazil. jl.diazdetuesta@ipb.pt.
FAU - Sayuri Berberich, Thais
AU  - Sayuri Berberich T
AD  - Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, 
      Campus Santa Apolonia, 5300-253, Braganca, Portugal.
AD  - Universidade Tecnologica Federal do Parana, Campus Ponta Grossa, 84017-220, Ponta 
      Grossa, Parana, Brazil. jl.diazdetuesta@ipb.pt.
FAU - Delezuk Inglez, Simone
AU  - Delezuk Inglez S
AD  - Universidade Tecnologica Federal do Parana, Campus Ponta Grossa, 84017-220, Ponta 
      Grossa, Parana, Brazil. jl.diazdetuesta@ipb.pt.
FAU - Bertao, Ana Raquel
AU  - Bertao AR
AD  - Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian 
      Nanotechnology Laboratory, Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal.
FAU - Caha, Ihsan
AU  - Caha I
AUID- ORCID: 0000-0002-8212-874X
AD  - Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian 
      Nanotechnology Laboratory, Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal.
FAU - Deepak, Francis Leonard
AU  - Deepak FL
AUID- ORCID: 0000-0002-3833-1775
AD  - Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian 
      Nanotechnology Laboratory, Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal.
FAU - Banobre-Lopez, Manuel
AU  - Banobre-Lopez M
AUID- ORCID: 0000-0003-4319-2631
AD  - Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian 
      Nanotechnology Laboratory, Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal.
FAU - Gomes, Helder Teixeira
AU  - Gomes HT
AD  - Centro de Investigacao de Montanha (CIMO), Instituto Politecnico de Braganca, 
      Campus Santa Apolonia, 5300-253, Braganca, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20220519
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Drug Carriers)
RN  - 0 (Magnetite Nanoparticles)
RN  - 7440-44-0 (Carbon)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Carbon
MH  - Doxorubicin/chemistry/pharmacology
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Hydrogen-Ion Concentration
MH  - *Magnetite Nanoparticles/chemistry
MH  - *Nanoparticles
EDAT- 2022/05/06 06:00
MHDA- 2022/05/21 06:00
CRDT- 2022/05/05 06:59
PHST- 2022/05/06 06:00 [pubmed]
PHST- 2022/05/21 06:00 [medline]
PHST- 2022/05/05 06:59 [entrez]
AID - 10.1039/d1nr08550f [doi]
PST - epublish
SO  - Nanoscale. 2022 May 19;14(19):7220-7232. doi: 10.1039/d1nr08550f.