PMID- 35511946
OWN - NLM
STAT- MEDLINE
DCOM- 20220613
LR  - 20221222
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 376
IP  - 6598
DP  - 2022 Jun 10
TI  - Circadian alignment of early onset caloric restriction promotes longevity in male 
      C57BL/6J mice.
PG  - 1192-1202
LID - 10.1126/science.abk0297 [doi]
AB  - Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does 
      so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour 
      feeding and 22-hour fasting, raising the question of if it is calories, fasting, 
      or time of day that is the cause of this increased life span. We show here that 
      30% CR was sufficient to extend the life span by 10%; however, a daily fasting 
      interval and circadian alignment of feeding acted together to extend life span by 
      35% in male C57BL/6J mice. These effects were independent of body weight. Aging 
      induced widespread increases in gene expression associated with inflammation and 
      decreases in the expression of genes encoding components of metabolic pathways in 
      liver from ad libitum-fed mice. CR at night ameliorated these aging-related 
      changes. Our results show that circadian interventions promote longevity and 
      provide a perspective to further explore mechanisms of aging.
FAU - Acosta-Rodriguez, Victoria
AU  - Acosta-Rodriguez V
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Rijo-Ferreira, Filipa
AU  - Rijo-Ferreira F
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
AD  - Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, USA.
FAU - Izumo, Mariko
AU  - Izumo M
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Xu, Pin
AU  - Xu P
AUID- ORCID: 0000-0003-1281-563X
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Wight-Carter, Mary
AU  - Wight-Carter M
AUID- ORCID: 0000-0002-0988-8582
AD  - Animal Resources Center, University of Texas Southwestern Medical Center, Dallas, 
      TX 75390, USA.
FAU - Green, Carla B
AU  - Green CB
AUID- ORCID: 0000-0002-3947-5156
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Takahashi, Joseph S
AU  - Takahashi JS
AUID- ORCID: 0000-0003-0384-8878
AD  - Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of 
      Texas Southwestern Medical Center, Dallas, TX 75390, USA.
AD  - Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, USA.
LA  - eng
GR  - R01 AG045795/AG/NIA NIH HHS/United States
GR  - K99 GM132557/GM/NIGMS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R56 AG072736/AG/NIA NIH HHS/United States
GR  - R35 GM127122/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20220505
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - Nat Rev Endocrinol. 2022 Aug;18(8):457. PMID: 35624140
CIN - Science. 2022 Jun 10;376(6598):1159-1160. PMID: 35679410
CIN - Signal Transduct Target Ther. 2022 Sep 9;7(1):314. PMID: 36085135
CIN - J Cardiovasc Aging. 2023;3(1):. PMID: 36544807
MH  - Animals
MH  - *Caloric Restriction
MH  - *Circadian Rhythm
MH  - Gene Expression Regulation
MH  - *Longevity/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
PMC - PMC9262309
MID - NIHMS1820506
COIS- Competing interests: The authors declare no competing interests.
EDAT- 2022/05/06 06:00
MHDA- 2022/06/14 06:00
PMCR- 2022/07/07
CRDT- 2022/05/05 14:04
PHST- 2022/05/06 06:00 [pubmed]
PHST- 2022/06/14 06:00 [medline]
PHST- 2022/05/05 14:04 [entrez]
PHST- 2022/07/07 00:00 [pmc-release]
AID - 10.1126/science.abk0297 [doi]
PST - ppublish
SO  - Science. 2022 Jun 10;376(6598):1192-1202. doi: 10.1126/science.abk0297. Epub 2022 
      May 5.