PMID- 35513492
OWN - NLM
STAT- MEDLINE
DCOM- 20220617
LR  - 20221113
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 18
IP  - 7
DP  - 2022 Jul
TI  - Epigenetics of type 2 diabetes mellitus and weight change - a tool for precision 
      medicine?
PG  - 433-448
LID - 10.1038/s41574-022-00671-w [doi]
AB  - Pioneering studies performed over the past few decades demonstrate links between 
      epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the 
      most rapidly increasing prevalence in the world. Importantly, these studies 
      identified epigenetic modifications, including altered DNA methylation, in 
      pancreatic islets, adipose tissue, skeletal muscle and the liver from individuals 
      with T2DM. As non-genetic factors that affect the risk of T2DM, such as obesity, 
      unhealthy diet, physical inactivity, ageing and the intrauterine environment, 
      have been associated with epigenetic modifications in healthy individuals, 
      epigenetics probably also contributes to T2DM development. In addition, genetic 
      factors associated with T2DM and obesity affect the epigenome in human tissues. 
      Notably, causal mediation analyses found DNA methylation to be a potential 
      mediator of genetic associations with metabolic traits and disease. In the past 
      few years, translational studies have identified blood-based epigenetic markers 
      that might be further developed and used for precision medicine to help patients 
      with T2DM receive optimal therapy and to identify patients at risk of 
      complications. This Review focuses on epigenetic mechanisms in the development of 
      T2DM and the regulation of body weight in humans, with a special focus on 
      precision medicine.
CI  - (c) 2022. Springer Nature Limited.
FAU - Ling, Charlotte
AU  - Ling C
AD  - Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University 
      Diabetes Centre, Lund University, Scania University Hospital, Malmo, Sweden. 
      Charlotte.Ling@med.lu.se.
FAU - Bacos, Karl
AU  - Bacos K
AUID- ORCID: 0000-0002-2461-9073
AD  - Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University 
      Diabetes Centre, Lund University, Scania University Hospital, Malmo, Sweden.
FAU - Ronn, Tina
AU  - Ronn T
AUID- ORCID: 0000-0001-7622-800X
AD  - Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University 
      Diabetes Centre, Lund University, Scania University Hospital, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220505
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
SB  - IM
MH  - DNA Methylation/genetics
MH  - *Diabetes Mellitus, Type 2/genetics/metabolism/therapy
MH  - Epigenesis, Genetic/genetics
MH  - Epigenomics
MH  - Humans
MH  - Obesity/complications/genetics
MH  - Precision Medicine
EDAT- 2022/05/06 06:00
MHDA- 2022/06/18 06:00
CRDT- 2022/05/05 23:21
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/05/06 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2022/05/05 23:21 [entrez]
AID - 10.1038/s41574-022-00671-w [pii]
AID - 10.1038/s41574-022-00671-w [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2022 Jul;18(7):433-448. doi: 10.1038/s41574-022-00671-w. Epub 
      2022 May 5.