PMID- 35514239
OWN - NLM
STAT- MEDLINE
DCOM- 20221102
LR  - 20221102
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Linking)
VI  - 21
IP  - 10
DP  - 2022 Oct
TI  - Platelet-rich plasma versus carboxytherapy in the treatment of periorbital dark 
      circles: A split-face study.
PG  - 4332-4338
LID - 10.1111/jocd.15051 [doi]
AB  - BACKGROUND: Periorbital hyperpigmentation is a recurrent problem in dermatologic 
      clinics that affect the patients' quality of life and their psychological status. 
      Platelet-rich plasma (PRP) may serve as a source of different growth factors 
      which may reduce the pigmentation in this problem. Carboxytherapy is carbon 
      dioxide infusion into human tissue for therapeutic purposes. OBJECTIVE: To 
      evaluate and compare the clinical efficacy of PRP and carboxytherapy in the 
      treatment of periorbital dark circles (PODC). Histopathological evaluation was 
      also done. PATIENTS AND METHODS: Split-face study of 23 patients with PODC 
      treated with PRP at the right side and carboxytherapy at the left side. Patients 
      received four sessions; one session/week. Final follow-up evaluation was done 
      3 months after the last session by clinical and histopathological assessment. 
      RESULTS: PRP showed significant better response (p = 0.002), shorter downtime, 
      and tolerable side effects than caboxytherapy. Reduction in area percent of 
      melanin after PRP injections showed 46.6% improvement, while after 
      carboxytherapy, it showed only 14.3% improvement. CONCLUSION: The present study 
      showed that PRP is more effective and tolerable than caboxytherapy in the 
      treatment of PODC.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - El-Tahlawi, Samar M
AU  - El-Tahlawi SM
AD  - Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Fawzy, Marwa M
AU  - Fawzy MM
AD  - Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - El Maadawi, Zeinab
AU  - El Maadawi Z
AD  - Department of Histology and cell biology Department, Faculty of Medicine, Cairo 
      University, Cairo, Egypt.
FAU - Yasen, Sara M
AU  - Yasen SM
AD  - Department of Dermatology, STDs & Andrology, Faculty of Medicine, Fayoum 
      University, Fayoum, Egypt.
FAU - Aboraia, Nesreen M
AU  - Aboraia NM
AD  - Department of Dermatology, STDs & Andrology, Faculty of Medicine, Fayoum 
      University, Fayoum, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220801
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
SB  - IM
MH  - Humans
MH  - Injections, Intradermal/adverse effects
MH  - Quality of Life
MH  - Patient Satisfaction
MH  - *Platelet-Rich Plasma
MH  - *Hyperpigmentation/radiotherapy/etiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - caboxytherapy
OT  - periorbital dark circles (PODC)
OT  - platelet-rich plasma (PRP)
EDAT- 2022/05/07 06:00
MHDA- 2022/11/03 06:00
CRDT- 2022/05/06 04:03
PHST- 2022/04/08 00:00 [revised]
PHST- 2022/04/08 00:00 [received]
PHST- 2022/04/29 00:00 [accepted]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/11/03 06:00 [medline]
PHST- 2022/05/06 04:03 [entrez]
AID - 10.1111/jocd.15051 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2022 Oct;21(10):4332-4338. doi: 10.1111/jocd.15051. Epub 2022 
      Aug 1.