PMID- 35514779
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220904
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 12
IP  - 2
DP  - 2022 Apr
TI  - Echocardiographic characteristics of patients with antisynthetase syndrome.
PG  - e12084
LID - 10.1002/pul2.12084 [doi]
LID - e12084
AB  - Right ventricular (RV) dysfunction and pulmonary hypertension (PH) occurs in 
      approximately one-third of patients with interstitial lung disease (ILD) and is 
      associated with reduced 6-minute walk distance (6MWD), and increased 
      hospitalizations and mortality. Although the impact of RV dysfunction and PH has 
      been well described in several types of ILD, data is scarce on antisynthetase 
      syndrome. Therefore, we sought to examine the presence of RV dysfunction and PH 
      in patients with antisynthetase syndrome and the impact on clinical outcomes. We 
      conducted a retrospective study of patients with antisynthetase syndrome. 
      Seventy-five subjects were identified. Fifty-one (68%) subjects had 
      echocardiographic data. Patients were grouped into those with normal fractional 
      area change (FAC) >/= 35% and reduced FAC < 35%. Clinical, echocardiographic, and 
      right heart catheterization data were compared between the two groups. Subjects 
      with FAC < 35% had lower diffusion capacity of the lung for carbon monoxide (29% 
      vs. 47%, p = 0.004), fibrotic features on computed tomography of the chest (79% 
      vs. 33%, p = 0.005), larger RV diameter (5.4 vs. 3.9 cm, p < 0.001), higher right 
      atrial pressures (8 vs. 5 mmHg, p = 0.02), and required supplemental oxygen more 
      frequently (100% vs. 44%, p < 0.001) compared to those with FAC >/= 35%. We found 
      no difference in 6MWD and hospitalizations between the two groups. The presence 
      of RV dysfunction in antisynthetase syndrome may identify patients at risk of 
      poor outcomes.
CI  - (c) 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on 
      behalf of Pulmonary Vascular Research Institute.
FAU - Bryan, Jaimie L
AU  - Bryan JL
AD  - College of Medicine University of Florida Gainesville Florida USA.
FAU - Matar, Ralph
AU  - Matar R
AD  - Division of Cardiovascular Medicine University of Florida Gainesville Florida 
      USA.
FAU - Raviprasad, Abheek
AU  - Raviprasad A
AD  - College of Medicine University of Florida Gainesville Florida USA.
FAU - Kuteyeva, Veronica
AU  - Kuteyeva V
AD  - College of Medicine University of Florida Gainesville Florida USA.
FAU - Milla, Eduardo
AU  - Milla E
AD  - Division of Internal Medicine University of Florida Gainesville Florida USA.
FAU - Begateri, Omkar
AU  - Begateri O
AD  - Division of Internal Medicine University of Florida Gainesville Florida USA.
FAU - Patel, Divya
AU  - Patel D
AD  - Division of Pulmonary, Critical Care and Sleep Medicine University of Florida 
      Gainesville Florida USA.
FAU - Manjarres, Diana G
AU  - Manjarres DG
AD  - Division of Pulmonary, Critical Care and Sleep Medicine University of Florida 
      Gainesville Florida USA.
FAU - Kalra, Saminder S
AU  - Kalra SS
AD  - Division of Pulmonary, Critical Care and Sleep Medicine University of Florida 
      Gainesville Florida USA.
FAU - Robinson, Jeffrey
AU  - Robinson J
AD  - Division of Pulmonary, Allergy and Critical Care Medicine Oregon Health and 
      Science University Portland Oregon USA.
FAU - Khan, Akram
AU  - Khan A
AD  - Division of Pulmonary, Allergy and Critical Care Medicine Oregon Health and 
      Science University Portland Oregon USA.
FAU - Reddy, Raju
AU  - Reddy R
AUID- ORCID: 0000-0002-3269-0136
AD  - Division of Pulmonary, Allergy and Critical Care Medicine Oregon Health and 
      Science University Portland Oregon USA.
LA  - eng
GR  - UL1 TR002369/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20220427
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC9063959
OTO - NOTNLM
OT  - antisynthetase syndrome
OT  - echocardiography
OT  - pulmonary hypertension
OT  - right ventricular dysfunction
COIS- The authors declare no conflicts of interest.
EDAT- 2022/05/07 06:00
MHDA- 2022/05/07 06:01
PMCR- 2022/04/27
CRDT- 2022/05/06 05:29
PHST- 2022/01/16 00:00 [received]
PHST- 2022/04/12 00:00 [revised]
PHST- 2022/04/12 00:00 [accepted]
PHST- 2022/05/06 05:29 [entrez]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/05/07 06:01 [medline]
PHST- 2022/04/27 00:00 [pmc-release]
AID - PUL212084 [pii]
AID - 10.1002/pul2.12084 [doi]
PST - epublish
SO  - Pulm Circ. 2022 Apr 27;12(2):e12084. doi: 10.1002/pul2.12084. eCollection 2022 
      Apr.