PMID- 35514822
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 9
IP  - 27
DP  - 2019 May 14
TI  - Highly sensitive AlGaN/GaN HEMT biosensors using an ethanolamine modification 
      strategy for bioassay applications.
PG  - 15341-15349
LID - 10.1039/c9ra02055a [doi]
AB  - In this paper, we propose a highly efficient surface modification strategy on an 
      AlGaN/GaN high electron mobility transistor (HEMT), where ethanolamine (EA) was 
      utilized to functionalize the surface of GaN and provided amphoteric amine groups 
      for probe molecular immobilization for bioassay application. The molecular 
      gated-AlGaN/GaN HEMT was utilized for pH and prostate-specific antigen (PSA) 
      detection to verify its performance as a biosensor. Benefitting from the high 
      coating quality on the GaN surface, the performance of our biosensor is 
      drastically improved compared to other AlGaN/GaN HEMT based pH and PSA biosensors 
      reported before. Our molecular gated-AlGaN/GaN HEMT biosensor has achieved good 
      static electrical performance for pH sensing, such as high sensitivity, good 
      linearity and chemical stability. Moreover, after further immobilization of PSA 
      antibody onto the EA aminated GaN surface, the limit of detection (LOD) for PSA 
      detection is as low as 1 fg mL(-1) in PBS buffer, which has reached an at least 
      two orders of magnitude decrease compared to any other AlGaN/GaN HEMT based PSA 
      biosensor reported before. And the sensitivity of our PSA biosensor has achieved 
      a substantial increase, reaching up to 2.04% for 100 ng mL(-1). The measurements 
      of pH and PSA utilizing the EA modified AlGaN/GaN HEMT biosensor indicate that 
      the surface modification strategy on the GaN proposed in this paper can 
      effectively improve the performance of the AlGaN/GaN HEMT based biosensor, which 
      demonstrates a promising application prospect in the AlGaN/GaN HEMT based 
      biological detection field.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Gu, Zhiqi
AU  - Gu Z
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China Hefei 230026 China.
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
FAU - Wang, Jin
AU  - Wang J
AUID- ORCID: 0000-0002-0610-202X
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
AD  - The College of Materials Sciences and Engineering, Shanghai University Shanghai 
      200444 China.
FAU - Miao, Bin
AU  - Miao B
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
AD  - Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Chinese 
      Academy of Sciences Suzhou 215125 People's Republic of China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
AD  - Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Chinese 
      Academy of Sciences Suzhou 215125 People's Republic of China.
AD  - The College of Nuclear Technology and Automation Engineering, Chengdu University 
      of Technology Chengdu 610059 China.
FAU - Liu, Xinsheng
AU  - Liu X
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
AD  - Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Chinese 
      Academy of Sciences Suzhou 215125 People's Republic of China.
AD  - The College of Nuclear Technology and Automation Engineering, Chengdu University 
      of Technology Chengdu 610059 China.
FAU - Wu, Dongmin
AU  - Wu D
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China Hefei 230026 China.
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
FAU - Li, Jiadong
AU  - Li J
AUID- ORCID: 0000-0002-0799-8710
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China Hefei 230026 China.
AD  - i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of 
      Sciences Suzhou 215125 People's Republic of China jdli2009@sinano.ac.cn.
AD  - Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Chinese 
      Academy of Sciences Suzhou 215125 People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190516
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9064203
COIS- There are no conflicts to declare.
EDAT- 2019/05/16 00:00
MHDA- 2019/05/16 00:01
PMCR- 2019/05/16
CRDT- 2022/05/06 05:30
PHST- 2019/03/17 00:00 [received]
PHST- 2019/05/09 00:00 [accepted]
PHST- 2022/05/06 05:30 [entrez]
PHST- 2019/05/16 00:00 [pubmed]
PHST- 2019/05/16 00:01 [medline]
PHST- 2019/05/16 00:00 [pmc-release]
AID - c9ra02055a [pii]
AID - 10.1039/c9ra02055a [doi]
PST - epublish
SO  - RSC Adv. 2019 May 16;9(27):15341-15349. doi: 10.1039/c9ra02055a. eCollection 2019 
      May 14.