PMID- 35515816
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1178-6965 (Print)
IS  - 1178-6965 (Electronic)
IS  - 1178-6965 (Linking)
VI  - 15
DP  - 2022
TI  - MALAT1 Induces Food Allergy by Promoting Release of IL-6 from Dendritic Cells and 
      Suppressing the Immunomodulatory Function of Tregs.
PG  - 529-544
LID - 10.2147/JAA.S341742 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) comprise a valuable target for 
      immune-modulation in food allergy (FA). Long noncoding RNA (lncRNA), metastasis 
      associated lung adenocarcinoma transcript 1 (MALAT1) has immunomodulatory 
      capacities and may influence the outcome of DC antigen presentation. However, the 
      precise molecular mechanisms underlying the implication of MALAT1 in FA remain 
      unclear. METHODS: BALB/c mice were sensitized to ovalbumin in accordance with a 
      model of FA protocol and injected with adenovirus. After modeling, 
      immunohistochemistry was performed to analyze the jejunal tissues of FA mice and 
      hematoxylin-eosin staining and toluidine blue staining were performed to detect 
      inflammation and mast cell numbers. Ovalbumin-sensitized mice were monitored for 
      symptoms of diarrhea and rectal temperature. Immature DCs were stimulated by 
      oxidized low density lipoprotein to trigger their maturation. RESULTS: MALAT1 was 
      found highly expressed in mice with FA, and its silencing relieved allergic 
      reactions with reduction in intestinal inflammatory cells and mast cells in FA 
      mice. MALAT1 aggravated symptoms by downregulating zinc finger protein 36 
      (ZFP36). MALAT1 also downregulated ZFP36 expression to promote interleukin-6 
      (IL-6) secretion by DCs and maturation of DCs, with increased serum-specific 
      immunoglobulin E (IgE) and IgG1 levels. CONCLUSION: Together, these data 
      suggested that therapeutically blocking MALAT1 in FA could reduce the severity of 
      FA by decreasing secretion of IL-6 by DCs and suppressing the immunomodulation of 
      Tregs.
CI  - (c) 2022 Feng et al.
FAU - Feng, Hua
AU  - Feng H
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, 330000, People's Republic of China.
AD  - School of Public Health, Nanchang University, Nanchang, 330006, People's Republic 
      of China.
FAU - Xiong, Xiujuan
AU  - Xiong X
AD  - Department of Pathology, Basic Medical College of Nanchang University, Nanchang, 
      330006, People's Republic of China.
FAU - Chen, Zhuo
AU  - Chen Z
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, 330000, People's Republic of China.
FAU - Luo, Nan
AU  - Luo N
AD  - School of Public Health, Nanchang University, Nanchang, 330006, People's Republic 
      of China.
FAU - Wu, Yongning
AU  - Wu Y
AUID- ORCID: 0000-0001-6430-1302
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang, 330000, People's Republic of China.
AD  - China National Center for Food Safety Risk Assessment, Beijing, 100022, People's 
      Republic of China.
AD  - Chinese Academy of Medical Science Research Unit, Beijing, 100730, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220429
PL  - New Zealand
TA  - J Asthma Allergy
JT  - Journal of asthma and allergy
JID - 101543450
PMC - PMC9064454
OTO - NOTNLM
OT  - Tregs
OT  - dendritic cells
OT  - food allergy
OT  - immunomodulation
OT  - interleukin 6
OT  - metastasis associated in lung adenocarcinoma transcript 1
OT  - zinc finger protein 36
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/07 06:00
MHDA- 2022/05/07 06:01
PMCR- 2022/04/29
CRDT- 2022/05/06 05:37
PHST- 2021/09/28 00:00 [received]
PHST- 2022/02/02 00:00 [accepted]
PHST- 2022/05/06 05:37 [entrez]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/05/07 06:01 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - 341742 [pii]
AID - 10.2147/JAA.S341742 [doi]
PST - epublish
SO  - J Asthma Allergy. 2022 Apr 29;15:529-544. doi: 10.2147/JAA.S341742. eCollection 
      2022.