PMID- 35518675
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 9
IP  - 15
DP  - 2019 Mar 12
TI  - Retracted Article: Structural characterization of Momordica charantia L. 
      (Cucurbitaceae) oligopeptides and the detection of their capability in non-small 
      cell lung cancer A549 cells: induction of apoptosis.
PG  - 8300-8309
LID - 10.1039/c9ra00090a [doi]
AB  - Oligopeptides are rarely reported from Chinese herbal medicine because they are 
      often present in very low concentrations in a complex matrix. Twenty-eight 
      oligopeptides were recently identified by high-performance liquid chromatography 
      and quadrupole-time-of-flight-mass spectrometry (HPLC-Q-TOF-MS) from Momordica 
      charantia L. (Cucurbitaceae), and a septapeptide, FHGKGHE 
      (Phe-His-Gly-Lys-Gly-His-Glu), named MCLO-12, showed the best anticancer activity 
      against the non-small cell lung cancer A549 cell line in vitro, with an IC(50) 
      value of 21.4 +/- 2.21 mM. The anti-proliferative activity assay results showed 
      that MCLO-12 induced apoptosis of A549 cells in a concentration-dependent manner. 
      Treatment of the cells with MCLO-12 (10.7-42.8 mM mL(-1)) caused strong 
      intracellular reactive oxygen species (ROS) up-regulating activities and 
      activated caspase expression. MCLO-12 also suppressed the Trx system and 
      subsequently activated a number of Trx-dependent pathways, including the ASK1, 
      MAPK-p38 and JNK pathways. Thus, our research provides a good reference point for 
      anti-NSCLC research into oligopeptides.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Dong, Jiao
AU  - Dong J
AD  - Department of Respiratory Medicine, Qilu Hospital of Shandong University Jinan 
      Shandong 250012 China quyiqing@sdu.edu.cn +86-531-86927544 +86-0531-82169335.
AD  - Department of Respiratory Medicine, Shandong Provincial Chest Hospital Jinan 
      250013 China.
FAU - Zhang, Xianxin
AU  - Zhang X
AD  - Department of Respiratory Medicine, Shandong Provincial Chest Hospital Jinan 
      250013 China.
FAU - Qu, Chunxiao
AU  - Qu C
AD  - Department of Pharmacy, Shandong Provincial Chest Hospital Jinan 250013 China.
FAU - Rong, Xuedong
AU  - Rong X
AD  - Department of Respiratory Medicine, Shandong Provincial Chest Hospital Jinan 
      250013 China.
FAU - Liu, Jie
AU  - Liu J
AD  - The Research Center of Allergy & Immunology, Shenzhen University School of 
      Medicine Shenzhen 518060 China lzgszuniversity@sina.com +86-0755-86671907 
      +86-0755-86671907.
FAU - Qu, Yiqing
AU  - Qu Y
AD  - Department of Respiratory Medicine, Qilu Hospital of Shandong University Jinan 
      Shandong 250012 China quyiqing@sdu.edu.cn +86-531-86927544 +86-0531-82169335.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20190312
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
RIN - RSC Adv. 2022 Apr 27;12(19):11612. PMID: 35503426
PMC - PMC9061805
COIS- The authors declare no conflicts of interest.
EDAT- 2019/03/12 00:00
MHDA- 2019/03/12 00:01
PMCR- 2019/03/12
CRDT- 2022/05/06 05:59
PHST- 2019/01/05 00:00 [received]
PHST- 2019/02/23 00:00 [accepted]
PHST- 2022/05/06 05:59 [entrez]
PHST- 2019/03/12 00:00 [pubmed]
PHST- 2019/03/12 00:01 [medline]
PHST- 2019/03/12 00:00 [pmc-release]
AID - c9ra00090a [pii]
AID - 10.1039/c9ra00090a [doi]
PST - epublish
SO  - RSC Adv. 2019 Mar 12;9(15):8300-8309. doi: 10.1039/c9ra00090a. eCollection 2019 
      Mar 12.