PMID- 35520953 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2589-9864 (Electronic) IS - 2589-9864 (Linking) VI - 19 DP - 2022 TI - Anti N-methyl-D-aspartate receptor (NMDAr) encephalitis during pregnancy: A case report. PG - 100535 LID - 10.1016/j.ebr.2022.100535 [doi] LID - 100535 AB - Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by reduced synaptic activity of the NMDAr due to circulating antibodies that target the NR1 subunit. Few cases of anti-NMDAR encephalitis during pregnancy have been described. The permeation of anti-NR1 antibodies through the placenta can be instrumental in the development of complications in newborns. We describe a case of a young woman suffering from anti-NMDAR encephalitis during the first trimester of pregnancy and focus on diagnostic and therapeutic management. CI - (c) 2022 The Author(s). FAU - Dono, Fedele AU - Dono F AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Center of Advance Studies and Technologies (CAST), "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. FAU - Evangelista, Giacomo AU - Evangelista G AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. FAU - Consoli, Stefano AU - Consoli S AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. FAU - Scorrano, Giovanna AU - Scorrano G AD - Department of Pediatrics, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. FAU - Russo, Mirella AU - Russo M AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. FAU - di Pietro, Martina AU - di Pietro M AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. FAU - Onofrj, Marco AU - Onofrj M AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Center of Advance Studies and Technologies (CAST), "G. d'Annunzio" University of Chieti-Pescara, Italy. FAU - Sensi, Stefano L AU - Sensi SL AD - Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Italy. AD - Center of Advance Studies and Technologies (CAST), "G. d'Annunzio" University of Chieti-Pescara, Italy. FAU - Anzellotti, Francesca AU - Anzellotti F AD - Epilepsy Center, "SS Annunziata" Hospital, Chieti, Italy. LA - eng PT - Case Reports DEP - 20220319 PL - United States TA - Epilepsy Behav Rep JT - Epilepsy & behavior reports JID - 101750909 PMC - PMC9062214 OTO - NOTNLM OT - Epilepsy OT - Fetal outcome OT - Lacosamide OT - Maternal outcome OT - Seizures COIS- The authors declare no conflict of interest. EDAT- 2022/05/07 06:00 MHDA- 2022/05/07 06:01 PMCR- 2022/03/19 CRDT- 2022/05/06 06:15 PHST- 2021/11/13 00:00 [received] PHST- 2021/12/30 00:00 [revised] PHST- 2022/03/13 00:00 [accepted] PHST- 2022/05/06 06:15 [entrez] PHST- 2022/05/07 06:00 [pubmed] PHST- 2022/05/07 06:01 [medline] PHST- 2022/03/19 00:00 [pmc-release] AID - S2589-9864(22)00012-0 [pii] AID - 100535 [pii] AID - 10.1016/j.ebr.2022.100535 [doi] PST - epublish SO - Epilepsy Behav Rep. 2022 Mar 19;19:100535. doi: 10.1016/j.ebr.2022.100535. eCollection 2022.