PMID- 35522033
OWN - NLM
STAT- MEDLINE
DCOM- 20220606
LR  - 20220716
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 45
IP  - 6
DP  - 2022 Jun 2
TI  - Carbohydrate Tolerance Threshold for Unannounced Snacks in Children and 
      Adolescents With Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System.
PG  - 1486-1488
LID - 10.2337/dc21-2643 [doi]
AB  - OBJECTIVE: To find a carbohydrate (CHO) tolerance threshold for unannounced 
      snacks to avoid the 2 h increase in glycemia (difference between pre- and 
      postmeal blood glucose [DeltaBG]) >/=50 mg/dL in advanced hybrid closed-loop (a-HCL) 
      users. RESEARCH DESIGN AND METHODS: Fourteen children and adolescents with type 1 
      diabetes (7 females; mean age [+/- SD] 14.5 +/- 3.6 years), users of the Medtronic 
      MiniMed 780G, participated in the study. For 12 days, they did not perform 
      insulin bolus before breakfasts, with defined different quantities and types of 
      CHO, with or without fats, performing blood glucose (BG) before and 2 h after the 
      meal. RESULTS: A cutoff of 19.8 g of total CHO was found to determine a DeltaBG of 50 
      mg/dL. BG never exceeded 250 mg/dL. Mean time in range was >/=70% in the 2 h 
      following each snack. CONCLUSIONS: Unannounced snacks of up to 20 g of CHO can 
      avoid DeltaBG >/=50 mg/dL in MiniMed 780G users, although unannounced meals of up to 30 
      g of CHO are safe.
CI  - (c) 2022 by the American Diabetes Association.
FAU - Tornese, Gianluca
AU  - Tornese G
AUID- ORCID: 0000-0002-4395-3915
AD  - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
FAU - Carletti, Claudia
AU  - Carletti C
AD  - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
FAU - Giangreco, Manuela
AU  - Giangreco M
AD  - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
FAU - Nistico, Daniela
AU  - Nistico D
AD  - Department of Medical Sciences, University of Trieste, Trieste, Italy.
FAU - Faleschini, Elena
AU  - Faleschini E
AD  - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
FAU - Barbi, Egidio
AU  - Barbi E
AD  - Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.
AD  - Department of Medical Sciences, University of Trieste, Trieste, Italy.
LA  - eng
SI  - figshare/10.2337/figshare.19491296
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose
MH  - Blood Glucose Self-Monitoring
MH  - Child
MH  - *Diabetes Mellitus, Type 1/drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/therapeutic use
MH  - Insulin Infusion Systems
MH  - Snacks
PMC - PMC9210515
EDAT- 2022/05/07 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/05/27
CRDT- 2022/05/06 08:53
PHST- 2021/12/21 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/05/06 08:53 [entrez]
PHST- 2022/05/27 00:00 [pmc-release]
AID - 146921 [pii]
AID - 212643 [pii]
AID - 10.2337/dc21-2643 [doi]
PST - ppublish
SO  - Diabetes Care. 2022 Jun 2;45(6):1486-1488. doi: 10.2337/dc21-2643.