PMID- 35522080
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231122
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 63
IP  - 29
DP  - 2023
TI  - An updated and comprehensive review on the potential health effects of 
      curcumin-encapsulated micro/nanoparticles.
PG  - 9731-9751
LID - 10.1080/10408398.2022.2070906 [doi]
AB  - Curcumin (CUR) is a natural hydrophobic compound, which is available in turmeric 
      rhizome. It has several bioactivities including antioxidant, anti-obesity, 
      anti-diabetic, cardioprotective, anti-inflammatory, antimicrobial, anticancer, 
      and other activities. Despite its medical and biological benefits, it is using in 
      limitations because of its hydrophobicity and sensitivity. These unfavorable 
      conditions further reduced the bioavailability (BA) and biological efficacy of 
      CUR. This review summarizes the stability and BA of free- and encapsulated-CUR, 
      as well as comprehensively discusses the potential biological activity of 
      CUR-loaded various micro-/nano-encapsulation systems. The stability and BA of CUR 
      can be improved via loading in different encapsulation systems, including 
      nanoemulsions, liposomes, niosomes, biopolymer-based nanoparticles, 
      nano-hydrogel, and others. Biopolymer-based nanoparticles (especially poly 
      lactic-co-glycolic acid (PLGA), zein, and chitosan) and nano-gels are the best 
      carriers for encapsulating and delivering CUR. Both delivery systems are suitable 
      because of their excellent functional properties such as high encapsulation 
      efficiency, well-stability against unfavorable conditions, and can be coated 
      using other encapsulation systems. Based on available evidences, encapsulated-CUR 
      exerted greater biological activities especially anticancer (breast cancer), 
      antioxidant, antidiabetic, and neuroprotective effects.
FAU - Rashwan, Ahmed K
AU  - Rashwan AK
AUID- ORCID: 0000-0002-9318-5256
AD  - Department of Food Science and Nutrition, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
AD  - Department of Food and Dairy Sciences, Faculty of Agriculture, South Valley 
      University, Qena, Egypt.
FAU - Karim, Naymul
AU  - Karim N
AUID- ORCID: 0000-0002-6515-0611
AD  - Department of Food Science and Nutrition, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
FAU - Xu, Yang
AU  - Xu Y
AD  - Department of Food Science and Nutrition, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
FAU - Hanafy, Nemany A N
AU  - Hanafy NAN
AUID- ORCID: 0000-0001-5861-6973
AD  - Nanomedicine Group, Institute of Nanoscience and Nanotechnology, Kafrelsheikh 
      University, Kafrelsheikh, Egypt.
FAU - Li, Bin
AU  - Li B
AUID- ORCID: 0000-0002-7393-2111
AD  - College of Food Science, Shenyang Agricultural University, Shenyang, China.
FAU - Mehanni, Abul-Hamd E
AU  - Mehanni AE
AUID- ORCID: 0000-0002-0229-6314
AD  - Department of Food Science and Nutrition, Faculty of Agriculture, Sohag 
      University, Sohag, Egypt.
FAU - Taha, Eman M
AU  - Taha EM
AUID- ORCID: 0000-0003-4054-2034
AD  - Department of Food and Dairy Sciences, Faculty of Agriculture, South Valley 
      University, Qena, Egypt.
FAU - Chen, Wei
AU  - Chen W
AUID- ORCID: 0000-0002-2373-2437
AD  - Department of Food Science and Nutrition, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
AD  - Ningbo Research Institute, Zhejiang University, Ningbo, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220506
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - IT942ZTH98 (Curcumin)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 0 (Drug Carriers)
RN  - 0 (Antioxidants)
RN  - 0 (Liposomes)
RN  - 0 (Biopolymers)
SB  - IM
MH  - Humans
MH  - *Curcumin/pharmacology
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Drug Carriers/chemistry
MH  - Antioxidants/pharmacology
MH  - *Nanoparticles/chemistry
MH  - Liposomes
MH  - Biopolymers
MH  - Particle Size
OTO - NOTNLM
OT  - Curcumin
OT  - bioavailability
OT  - biological activity
OT  - clinical studies
OT  - encapsulation systems
OT  - stability
EDAT- 2022/05/07 06:00
MHDA- 2023/11/15 06:42
CRDT- 2022/05/06 09:23
PHST- 2023/11/15 06:42 [medline]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/05/06 09:23 [entrez]
AID - 10.1080/10408398.2022.2070906 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2023;63(29):9731-9751. doi: 
      10.1080/10408398.2022.2070906. Epub 2022 May 6.