PMID- 35524095
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20220923
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 44
DP  - 2022 Sep
TI  - Associations between organophosphate esters metabolites and sleep disorder and 
      trouble sleeping in adults: a machine-learning approach.
PG  - 67287-67300
LID - 10.1007/s11356-022-20596-1 [doi]
AB  - Organophosphate esters (OPEs) are used widely as flame retardants and 
      plasticizers. However, the associations between OPEs metabolites and sleep 
      outcomes (sleep disorder and trouble sleeping) remain unknown. Data utilized in 
      this cross-sectional study was from the National Health and Nutrition Examination 
      Survey 2013-2014, including 1393 adults aged >/= 20 years. We conducted weighted 
      logistic regression and Bayesian kernel machine regression (BKMR) models to 
      analyze the associations between OPEs metabolites and sleep outcomes. We included 
      data from 2011 to 2012 cycle in our sensitivity analysis to explore the 
      association further. Logistic regression model presented a significant positive 
      association between diphenyl phosphate (DPHP) and sleep disorder in all 
      participants (odds ratio (95% confidence interval) for the second quartile was 
      2.46 (1.85, 3.28)). We observed positive associations between OPEs metabolites 
      and sleep outcomes in males. Among females, no significant association was 
      observed in the logistic model. BKMR presented that dibutyl phosphate (DBUP) was 
      the relatively important exposure. There was a positive association between OPEs 
      metabolites mixture and trouble sleeping. Univariable exposure-response functions 
      demonstrated U-shaped associations between DBUP and sleep outcomes, while 
      bis(2-chloroethyl) phosphate (BCEP) was associated with sleep disorder negatively 
      in females. No substantial changes appeared in the results after including the 
      data from 2011 to 2012 cycle. This current study indicated that OPEs metabolites 
      might be associated with sleep disorder and trouble sleeping, and the 
      associations seemed to be sex-dependent.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Kang, Xiao
AU  - Kang X
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No.308 Ningxia Road, Qingdao, 266021, China.
FAU - Li, Jingxian
AU  - Li J
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No.308 Ningxia Road, Qingdao, 266021, China.
FAU - Luo, Jia
AU  - Luo J
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No.308 Ningxia Road, Qingdao, 266021, China.
FAU - Zhang, Dongfeng
AU  - Zhang D
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No.308 Ningxia Road, Qingdao, 266021, China. 
      zhangdf1961@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220506
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Esters)
RN  - 0 (Flame Retardants)
RN  - 0 (Organophosphates)
RN  - 0 (Phosphates)
RN  - 0 (Plasticizers)
RN  - 107-66-4 (di-n-butylphosphoric acid)
SB  - IM
MH  - Adult
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - Esters
MH  - Female
MH  - *Flame Retardants/metabolism
MH  - Humans
MH  - Machine Learning
MH  - Male
MH  - Nutrition Surveys
MH  - Organophosphates
MH  - Phosphates
MH  - Plasticizers
MH  - *Sleep Wake Disorders
OTO - NOTNLM
OT  - Adults
OT  - Bayesian kernel machine regression
OT  - NHANES
OT  - Organophosphate esters metabolites
OT  - Sleep disorder
OT  - Trouble sleeping
EDAT- 2022/05/07 06:00
MHDA- 2022/09/24 06:00
CRDT- 2022/05/06 23:34
PHST- 2021/11/09 00:00 [received]
PHST- 2022/04/29 00:00 [accepted]
PHST- 2022/05/07 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/05/06 23:34 [entrez]
AID - 10.1007/s11356-022-20596-1 [pii]
AID - 10.1007/s11356-022-20596-1 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Sep;29(44):67287-67300. doi: 
      10.1007/s11356-022-20596-1. Epub 2022 May 6.