PMID- 35524680
OWN - NLM
STAT- MEDLINE
DCOM- 20220720
LR  - 20220721
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 43
IP  - 12
DP  - 2022 Aug 15
TI  - Abnormal dynamic functional connectivity after sleep deprivation from temporal 
      variability perspective.
PG  - 3824-3839
LID - 10.1002/hbm.25886 [doi]
AB  - Sleep deprivation (SD) is very common in modern society and regarded as a 
      potential causal mechanism of several clinical disorders. Previous neuroimaging 
      studies have explored the neural mechanisms of SD using magnetic resonance 
      imaging (MRI) from static (comparing two MRI sessions [one after SD and one after 
      resting wakefulness]) and dynamic (using repeated MRI during one night of SD) 
      perspectives. Recent SD researches have focused on the dynamic functional brain 
      organization during the resting-state scan. Our present study adopted a novel 
      metric (temporal variability), which has been successfully applied to many 
      clinical diseases, to examine the dynamic functional connectivity after SD in 55 
      normal young subjects. We found that sleep-deprived subjects showed increased 
      regional-level temporal variability in large-scale brain regions, and decreased 
      regional-level temporal variability in several thalamus subregions. After SD, 
      participants exhibited enhanced intra-network temporal variability in the default 
      mode network (DMN) and increased inter-network temporal variability in numerous 
      subnetwork pairs. Furthermore, we found that the inter-network temporal 
      variability between visual network and DMN was negative related with the slowest 
      10% respond speed (beta = -.42, p = 5.57 x 10(-4) ) of the psychomotor vigilance 
      test after SD following the stepwise regression analysis. In conclusion, our 
      findings suggested that sleep-deprived subjects showed abnormal dynamic brain 
      functional configuration, which provides new insights into the neural 
      underpinnings of SD and contributes to our understanding of the pathophysiology 
      of clinical disorders.
CI  - (c) 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
FAU - Sun, Jinbo
AU  - Sun J
AUID- ORCID: 0000-0001-6868-9164
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Sciences and Technology, Xidian University, Xi'an, 
      China.
AD  - Intelligent Non-invasive Neuromodulation Technology and Transformation Joint 
      Laboratory, Xidian University, Xi'an, China.
FAU - Zhao, Rui
AU  - Zhao R
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - He, Zhaoyang
AU  - He Z
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - Chang, Mengying
AU  - Chang M
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - Wang, Fumin
AU  - Wang F
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - Wei, Wei
AU  - Wei W
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - Zhang, Xiaodan
AU  - Zhang X
AD  - School of Electronics and Information, Xi'an Polytechnic University, Xi'an, 
      China.
FAU - Zhu, Yuanqiang
AU  - Zhu Y
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University, 
      Xi'an, China.
FAU - Xi, Yibin
AU  - Xi Y
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University, 
      Xi'an, China.
AD  - Department of Radiology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, 
      China.
FAU - Yang, Xuejuan
AU  - Yang X
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Sciences and Technology, Xidian University, Xi'an, 
      China.
AD  - Intelligent Non-invasive Neuromodulation Technology and Transformation Joint 
      Laboratory, Xidian University, Xi'an, China.
FAU - Qin, Wei
AU  - Qin W
AUID- ORCID: 0000-0003-4583-0406
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Sciences and Technology, Xidian University, Xi'an, 
      China.
AD  - Intelligent Non-invasive Neuromodulation Technology and Transformation Joint 
      Laboratory, Xidian University, Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220507
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Brain/physiology
MH  - *Brain Mapping
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways/physiology
MH  - Rest
MH  - *Sleep Deprivation/diagnostic imaging
PMC - PMC9294309
OTO - NOTNLM
OT  - dynamic functional connectivity
OT  - psychomotor vigilance test
OT  - resting-state functional magnetic resonance imaging
OT  - sleep deprivation
OT  - temporal variability
COIS- The authors declare no potential conflict of interest.
EDAT- 2022/05/08 06:00
MHDA- 2022/07/22 06:00
PMCR- 2022/05/07
CRDT- 2022/05/07 06:52
PHST- 2022/04/07 00:00 [revised]
PHST- 2022/01/20 00:00 [received]
PHST- 2022/04/08 00:00 [accepted]
PHST- 2022/05/08 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2022/05/07 06:52 [entrez]
PHST- 2022/05/07 00:00 [pmc-release]
AID - HBM25886 [pii]
AID - 10.1002/hbm.25886 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2022 Aug 15;43(12):3824-3839. doi: 10.1002/hbm.25886. Epub 2022 
      May 7.