PMID- 35524738
OWN - NLM
STAT- MEDLINE
DCOM- 20220822
LR  - 20220822
IS  - 1365-2230 (Electronic)
IS  - 0307-6938 (Linking)
VI  - 47
IP  - 9
DP  - 2022 Sep
TI  - Pyoderma gangrenosum-like skin ulceration in antineutrophil cytoplasmic 
      antibody-associated vasculitis: a retrospective case series.
PG  - 1716-1719
LID - 10.1111/ced.15251 [doi]
AB  - Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can be associated 
      with various cutaneous manifestations. Several case reports have described skin 
      ulceration resembling pyoderma gangrenosum (PG), particularly in granulomatosis 
      with polyangiitis (GPA); however, the true incidence of this PG-like ulceration 
      in various diseases is unknown. In addition, PG is frequently misdiagnosed, and 
      diagnosis may rely on exclusion of other causes of ulcers. We aimed to describe 
      clinical and histopathological features of PG-like ulcerations occurring in 
      association with AAV and identify clues to differentiate these ulcers from PG. 
      Retrospective search was conducted to include patients with AAV presenting with 
      PG-like ulcers treated at our institution. This large case series highlights 
      presentation of PG-like ulcers occurring in patients with AAV. Care should be 
      taken to avoid delayed or missed diagnosis of AAV. Distinction between AAV and PG 
      is challenging yet mandatory for proper treatment. Diagnosis relies on a 
      constellation of detailed cutaneous clinical examination, systemic symptoms or 
      illness, histopathological features and laboratory tests.
CI  - (c) 2022 British Association of Dermatologists.
FAU - Shakshouk, Hadir
AU  - Shakshouk H
AUID- ORCID: 0000-0002-0047-3292
AD  - Department of1Dermatology, Mayo Clinic, Rochester, MN, USA.
FAU - Gibson, Lawrence E
AU  - Gibson LE
AD  - Department of1Dermatology, Mayo Clinic, Rochester, MN, USA.
AD  - Department of 2Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20220703
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Granulomatosis with Polyangiitis/complications/diagnosis/drug therapy
MH  - Humans
MH  - *Pyoderma Gangrenosum/drug therapy
MH  - Retrospective Studies
MH  - *Skin Ulcer/etiology
MH  - Ulcer
EDAT- 2022/05/08 06:00
MHDA- 2022/08/23 06:00
CRDT- 2022/05/07 09:03
PHST- 2022/05/05 00:00 [accepted]
PHST- 2022/05/08 06:00 [pubmed]
PHST- 2022/08/23 06:00 [medline]
PHST- 2022/05/07 09:03 [entrez]
AID - 10.1111/ced.15251 [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2022 Sep;47(9):1716-1719. doi: 10.1111/ced.15251. Epub 2022 
      Jul 3.